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Association of cigarette smoking with cognitive impairment in male patients with chronic schizophrenia

文献类型：期刊论文

作者Wei, Shuochi1,2; Wang, Dongmei1,2; Wei, Gaoxia1,2; Wang, Jiesi1,2; Zhou, Huixia1,2; Xu, Hang1,2; Xia, Luyao1,2; Tian, Yang1,2; Dai, Qilong1,2; Zhu, Rongrong1,2
刊名PSYCHOPHARMACOLOGY
出版日期2020-08-05
页码8
关键词Schizophrenia Smoking Cognitive Nicotine Memory
ISSN号0033-3158
DOI10.1007/s00213-020-05621-w
通讯作者Zhang, Xiang Yang(zhangxy@psych.ac.cn)
英文摘要Background Previous studies have shown that patients with schizophrenia have higher smoking rates and worse cognitive function than healthy controls. However, there is no consistent conclusion about the relationship between smoking and cognitive impairment. Objectives The main purpose of this study was to explore the effects of smoking on cognitive function by using MATRICS Cognitive Consensus Battery (MCCB) in Chinese male patients with schizophrenia. Methods There were 164 patients with chronic schizophrenia and 82 healthy controls. All subjects were interviewed about smoking status. The cognitive function was assessed by MCCB and Stroop tests. The Positive and Negative Syndrome Scale (PANSS) was used to assess the clinical symptoms of the patients. Results Compared with healthy controls, patients had lower MCCB scores in all of its domain scores (allp< 0.05). In the patients, the scores of spatial span test (42.3 +/- 11.6), digital sequence test (42.9 +/- 10.6), and Hopkins Verbal Learning Test (42.2 +/- 10.1) were lower in smokers than those in nonsmokers (allp< 0.05, effect size: 0.28-0.45). Logistic regression analysis showed that the smoking status of the patients was correlated with digital sequence score (p< 0.05, OR = 1.072, 95%CI: 1.013-1.134). Multivariate regression analysis showed that the spatial span total score (beta= - 0.26,t= - 2.74,p< 0.001) was associated with the duration of smoking in patients with schizophrenia. Conclusions Our findings show that smoking patients with chronic schizophrenia exhibit more severe cognitive impairment than nonsmoking patients, especially in working memory and executive function.
WOS关键词1ST-EPISODE DRUG-NAIVE ; TOBACCO SMOKING ; OXIDATIVE STRESS ; WORKING-MEMORY ; BATTERY ; METAANALYSIS ; PERFORMANCE ; ABSTINENCE ; HYPOTHESIS ; PSYCHOSIS
资助项目National Natural Science Foundation of China[81371477] ; CAS Pioneer Hundred Talents Program
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种英语
WOS记录号WOS:000556172400001
出版者SPRINGER
资助机构National Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program
源URL[http://ir.psych.ac.cn/handle/311026/32344]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Xiang Yang
作者单位1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Beijing HuiLongGuan Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Shuochi,Wang, Dongmei,Wei, Gaoxia,et al. Association of cigarette smoking with cognitive impairment in male patients with chronic schizophrenia[J]. PSYCHOPHARMACOLOGY,2020:8.
APA Wei, Shuochi.,Wang, Dongmei.,Wei, Gaoxia.,Wang, Jiesi.,Zhou, Huixia.,...&Zhang, Xiang Yang.(2020).Association of cigarette smoking with cognitive impairment in male patients with chronic schizophrenia.PSYCHOPHARMACOLOGY,8.
MLA Wei, Shuochi,et al."Association of cigarette smoking with cognitive impairment in male patients with chronic schizophrenia".PSYCHOPHARMACOLOGY (2020):8.

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来源：心理研究所

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