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Posttraumatic Stress Disorder and Nonadherence to Treatment in People Living With HIV: A Systematic Review and Meta-analysis

文献类型：期刊论文

作者Hou, Jianhua1,2; Fu, Jiangning3; Meng, Siyan4; Jiang, Taiyi1; Guo, Caiping1; Wu, Hao1,2; Su, Bin1,2; Zhang, Tong1,2
刊名FRONTIERS IN PSYCHIATRY
出版日期2020-08-19
卷号11页码:8
ISSN号1664-0640
关键词posttraumatic stress disorder people living with HIV meta-analysis antiretroviral therapy adherence systematic review
DOI10.3389/fpsyt.2020.00834
通讯作者Zhang, Tong(zt_doc@ccmu.edu.cn)
英文摘要Background Posttraumatic stress disorder (PTSD) is a commonly reported and serious complication among people living with HIV (PLWH). PTSD may significantly increase unintentional non-adherence to antiretroviral therapy. In this systematic review and meta-analysis, we aimed to pool the observational studies exploring the association between PTSD and medication adherence among PLWH. Methods Comprehensive searches were conducted in PubMed/Medline, Web of Science, PsycINFO, Google Scholar, and ProQuest to identify relevant articles and dissertations. A random effects meta-analysis with inverse variance weighting was used to summarize the odds ratio (OR) across studies. Meta-regression and subgroup analyses were also carried out to assess the moderation effects for potential factors. Results By synthesizing 12 studies comprising 2489 participants, the pooled odd ratio of non-adherence to antiretroviral therapy was 1.19 (95% confidential interval (CI), 1.03-1.37,p= 0.02). No significant publication bias was detected by Egger's test (Intercept = 0.842,p= 0.284). Factors moderating the association were mean age of participants, depression adjustment, and depression (allp< 0.05). Conclusions This meta-analysis supports that PTSD is related to adherence in PLWH. The hypothesized mechanisms (avoidant behavior and cognitive impairment) underlying this association need further investigation. Overall, this study highlights that clinicians should thoughtfully integrate timely mental health intervention into routine care.
WOS关键词ANTIRETROVIRAL MEDICATION ADHERENCE ; PROSPECTIVE MEMORY ; DISEASE PROGRESSION ; SOCIAL SUPPORT ; DEPRESSION ; SYMPTOMS ; IMPACT ; PTSD ; THERAPY ; HIV/AIDS
资助项目National Science and Technology Major Project: the National 13th Five-Year Grand Program on Key Infectious Disease Control[2017ZX10202102005-003] ; National Science and Technology Major Project: the National 13th Five-Year Grand Program on Key Infectious Disease Control[2018ZX10301-407-005] ; National Science and Technology Major Project: the National 13th Five-Year Grand Program on Key Infectious Disease Control[2018ZX10302103001-003] ; National Science and Technology Major Project: the National 13th Five-Year Grand Program on Key Infectious Disease Control[2018ZX10715-005-002-002] ; National Science and Technology Major Project: the National 13th Five-Year Grand Program on Key Infectious Disease Control[2017ZX10202101-004-001] ; Beijing Municipal of Science and Technology Major Project[D161100000416003] ; Beijing Municipal of Science and Technology Major Project[D161100000416005] ; Beijing Key Laboratory for HIV/AIDS Research[BZ0089]
WOS研究方向Psychiatry
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000566187500001
资助机构National Science and Technology Major Project: the National 13th Five-Year Grand Program on Key Infectious Disease Control ; Beijing Municipal of Science and Technology Major Project ; Beijing Key Laboratory for HIV/AIDS Research
源URL[http://ir.psych.ac.cn/handle/311026/32618]  
专题心理研究所_健康与遗传心理学研究室
通讯作者Zhang, Tong
作者单位1.Capital Med Univ, Beijing Youan Hosp, Ctr Infect Dis, Beijing, Peoples R China
2.Beijing Key Lab HIV AIDS Res, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
4.Yale Univ, Sch Publ Hlth, New Haven, CT USA
推荐引用方式
GB/T 7714		 Hou, Jianhua,Fu, Jiangning,Meng, Siyan,et al. Posttraumatic Stress Disorder and Nonadherence to Treatment in People Living With HIV: A Systematic Review and Meta-analysis[J]. FRONTIERS IN PSYCHIATRY,2020,11:8.
APA Hou, Jianhua.,Fu, Jiangning.,Meng, Siyan.,Jiang, Taiyi.,Guo, Caiping.,...&Zhang, Tong.(2020).Posttraumatic Stress Disorder and Nonadherence to Treatment in People Living With HIV: A Systematic Review and Meta-analysis.FRONTIERS IN PSYCHIATRY,11,8.
MLA Hou, Jianhua,et al."Posttraumatic Stress Disorder and Nonadherence to Treatment in People Living With HIV: A Systematic Review and Meta-analysis".FRONTIERS IN PSYCHIATRY 11(2020):8.

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来源：心理研究所

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