Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder
文献类型：期刊论文
| 作者 | Wang, Xiaoming1,2; Cui, Shaojuan4; Wu, Michael Shengtao5; Wang, Yun3,6; Gao, Qinglin1,2; Zhou, Yuan1,2,3,6
|
| 刊名 | FRONTIERS IN PSYCHIATRY
 |
| 出版日期 | 2020-08-11 |
| 卷号 | 11页码:9 |
| 关键词 | victim sensitivity major depressive disorder dorsolateral prefrontal cortex fractional amplitude of low-frequency fluctuation resting-state fMRI |
| ISSN号 | 1664-0640 |
| DOI | 10.3389/fpsyt.2020.00622 |
| 通讯作者 | Zhou, Yuan(zhouyuan@psych.ac.cn) |
| 英文摘要 | Background Dysfunctional beliefs about the self are common in the development of depressive symptoms, but it remains unclear how depressed patients respond to unfair treatment, both dispositionally and neurally. The present research is an attempt to explore the differences in sensitivity to injustice as a victim and its neural correlates in patients with major depressive disorder (MDD) versus healthy controls. Methods First episodic, drug-naive patients with MDD (n= 30) and a control group (n= 30) were recruited to compare their differences in victim sensitivity. A second group of patients with MDD (n= 23) and their controls (n= 28) were recruited to replicate the findings and completed resting-state functional magnetic resonance imaging (fMRI) scanning. Spontaneous brain activity measured by fractional amplitude of low-frequency fluctuation (fALFF) was used to characterize the neural correlates of victim sensitivity both in patients and in healthy controls. Results Higher victim sensitivity was consistently found in patients with MDD than healthy controls in both datasets. Multiple regression analysis on the fALFF showed a significant interaction effect between diagnosis and victim sensitivity in the right dorsolateral prefrontal cortex (DLPFC). Conclusions The patients with MDD show higher sensitivity to injustice as a victim, which may be independent of their disease course. The MDD patients differ from healthy controls in the neural correlates of victim sensitivity. These findings shed light on the linkage between cognitive control subserved by the DLPFC and negative bias towards the self implicated by higher victim sensitivity among the depressed patients. |
| WOS关键词 | COGNITIVE-CONTROL ; JUSTICE SENSITIVITY ; FUNCTIONAL CONNECTIVITY ; DECISION-MAKING ; ULTIMATUM GAME ; RESTING STATE ; BRAIN ; FMRI ; METAANALYSIS ; ASSOCIATION |
| 资助项目 | Natural Science Foundation of China[81771473] ; State High-Tech Development Plan of China (863)[2015AA020513] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000565650600001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | Natural Science Foundation of China ; State High-Tech Development Plan of China (863) |
| 源URL | [http://ir.psych.ac.cn/handle/311026/32621]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Zhou, Yuan |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 3.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 4.Capital Med Univ, Beijing Tongren Hosp, Dept Psychol, Beijing, Peoples R China 5.Xiamen Univ, Sch Sociol & Anthropol, Xiamen, Peoples R China 6.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaoming,Cui, Shaojuan,Wu, Michael Shengtao,et al. Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder[J]. FRONTIERS IN PSYCHIATRY,2020,11:9. |
| APA | Wang, Xiaoming,Cui, Shaojuan,Wu, Michael Shengtao,Wang, Yun,Gao, Qinglin,&Zhou, Yuan.(2020).Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder.FRONTIERS IN PSYCHIATRY,11,9. |
| MLA | Wang, Xiaoming,et al."Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder".FRONTIERS IN PSYCHIATRY 11(2020):9. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。