Sex differences in the association between symptoms and superoxide dismutase in patients with never-treated first-episode schizophrenia
文献类型：期刊论文
| 作者 | Wang, Dong Mei2,3; Chen, Da Chun1; Wang, Li2,3 ; Zhang, Xiang Yang2,3
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| 刊名 | WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
 |
| 出版日期 | 2020-08-26 |
| 页码 | 10 |
| 关键词 | Sex differences SOD schizophrenia first-episode PANSS |
| ISSN号 | 1562-2975 |
| DOI | 10.1080/15622975.2020.1805510 |
| 通讯作者 | Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Objectives Considering the sex differences and oxidative stress in the pathophysiological mechanism of schizophrenia (SCZ), we explored the sex differences in clinical characteristics and superoxide dismutase (SOD) activity as well as their relationship in never-treated first-episode (NTFE) patients with SCZ in the Han Chinese population, which has not been reported yet. Methods Total SOD and manganese SOD (MnSOD) activities were examined in 165 NTFE patients with SCZ (male/female = 98/67) and 133 healthy controls (male/female =70/63). Psychopathological symptoms were evaluated by a five-factor model of the Positive and Negative Syndrome Scale (PANSS). Results SCZ patients had higher plasma total SOD activity than healthy controls (p < .01). In healthy controls, the total SOD activity was significantly higher in males than that in females (p < .001), but not in patients group (p > .05). Further, Multiple regression analysis revealed that in male patients, the PANSS depressive factor was independently positively correlated with MnSOD or total SOD activity (bothp < .01), while in female patients, the MnSOD activity was positively related to the PANSS positive symptom score (p < .05). Conclusions Our findings indicate sex differences in the relationship between SOD activities and psychopathological symptoms in the early stage of SCZ. |
| WOS关键词 | ANTIOXIDANT ENZYME-ACTIVITIES ; NEGATIVE SYNDROME SCALE ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; CEREBROSPINAL-FLUID ; GENDER-DIFFERENCES ; AGE ; HALOPERIDOL ; PSYCHOSIS ; EXERCISE |
| 资助项目 | National Key Research and Development Program of China[2017YFC1310405] ; CAS International Cooperation Research Program[153111KYSB20190004] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000566570000001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | National Key Research and Development Program of China ; CAS International Cooperation Research Program ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
| 源URL | [http://ir.psych.ac.cn/handle/311026/32637]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang Yang |
| 作者单位 | 1.Beijing HuiLongGuan Hosp, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Dong Mei,Chen, Da Chun,Wang, Li,et al. Sex differences in the association between symptoms and superoxide dismutase in patients with never-treated first-episode schizophrenia[J]. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,2020:10. |
| APA | Wang, Dong Mei,Chen, Da Chun,Wang, Li,&Zhang, Xiang Yang.(2020).Sex differences in the association between symptoms and superoxide dismutase in patients with never-treated first-episode schizophrenia.WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,10. |
| MLA | Wang, Dong Mei,et al."Sex differences in the association between symptoms and superoxide dismutase in patients with never-treated first-episode schizophrenia".WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2020):10. |
入库方式： OAI收割
来源：心理研究所
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