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Discovering Traditional Chinese Medicinal Herbs for Neurodegenerative Disorders

文献类型：期刊论文

作者Liu, Xuewei2; Jia, Caixia5; Wu, Chuanhong4; Wang, Na2; Jia, Yongming2; Zhu, Yongtao5; Li, Pengyue5; Ghulam, Murtaza3; Zhang, Kunlin1,6
刊名INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
出版日期2020
卷号82页码:70-+
关键词Neurodegenerative disorders susceptibility gene traditional Chinese medicine herbs Alzheimer's disease resveratrol
ISSN号0250-474X
DOI10.36468/pharmaceutical-sciences.sp1.63
通讯作者Ghulam, Murtaza(gmdogar356@gmail.com) ; Zhang, Kunlin(zhangkl@psych.ac.cn)
英文摘要In this investigation, candidate traditional Chinese medicinal herbs for 3 neurodegenerative disorders, late-onset Alzheimer's disease, late-onset Parkinson's disease and Huntington disease were evaluated. The susceptibility genes were integrated to reconstruct traditional Chinese medicine-modern medicine network to discover the candidate herbs. For the 3 neurodegenerative disorders, the number of diseaserelated genes were increased from 2 to 16, which are directly associated with ingredients. Many traditional Chinese medicinal herbs associated with the 3 neurodegenerative disorders were identified (false discovery rate Benjamini-Hochberg<0.05). Four herbs for late-onset Alzheimer's disease are related to P-amyloid 1-42 measurement-associated genes BCAM and APOE by ingredients resveratrol and kainic acid. There are 3 herbs correlated to late-onset Parkinson's disease by both ingredient support and modern medicine symptom association evidence. Four traditional Chinese medicinal herbs are related to Huntington disease by ingredients. Available animal experiments in rats indicated that resveratrol could help to clean p-amyloid in brain to treat Alzheimer's disease, probably through targeting LRP1 protein. This study provided a novel way to utilize genetic data to explore traditional Chinese medicinal herbs and a new insight into drug discovery of neurodegenerative disorders.
资助项目National Natural Science Foundation of China[31470070] ; Fundamental Research Funds for the Central Universities[2018-JYB-XJQ-007] ; Fundamental Research Funds for the Central Universities[1000061020051]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000566973300014
出版者INDIAN PHARMACEUTICAL ASSOC
资助机构National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
源URL[http://ir.psych.ac.cn/handle/311026/32860]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Ghulam, Murtaza; Zhang, Kunlin
作者单位1.Chinese Acad Sci, Inst Psychol, Ctr Genet & BioMed Informat Res, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Qiqihar Med Univ, Coll Pharm, Qiqihar 161006, Peoples R China
3.COMSATS Univ Islamabad, Dept Pharm, Lahore Campus, Islamabad, Pakistan
4.Qingdao Univ, Biomed Sci Inst, Qingdao Branch, SJTU BioX Inst, Qingdao 266071, Peoples R China
5.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Xuewei,Jia, Caixia,Wu, Chuanhong,et al. Discovering Traditional Chinese Medicinal Herbs for Neurodegenerative Disorders[J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2020,82:70-+.
APA Liu, Xuewei.,Jia, Caixia.,Wu, Chuanhong.,Wang, Na.,Jia, Yongming.,...&Zhang, Kunlin.(2020).Discovering Traditional Chinese Medicinal Herbs for Neurodegenerative Disorders.INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES,82,70-+.
MLA Liu, Xuewei,et al."Discovering Traditional Chinese Medicinal Herbs for Neurodegenerative Disorders".INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES 82(2020):70-+.

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来源：心理研究所

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