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Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia

文献类型：期刊论文

作者Dong, Rui5; Yuan, Lian6; Yang, Yong2; Du, Xiang-Dong2; Jia, Qiufang2; Dillon, Brett A.3; Yu, Liling5; Zhang, Xiang Yang1,4
刊名HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
出版日期2020-09-17
页码8
关键词clozapine cognition risperidone schizophrenia typical antipsychotic drugs
ISSN号0885-6222
DOI10.1002/hup.2754
通讯作者Yu, Liling(liling07@ccmu.edu.cn) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
英文摘要Background Cognitive impairment is core feature of schizophrenia. The impact of antipsychotics on cognition remains controversial. This study aimed to examine the effects of long-term use of different types of antipsychotics on cognitive impairment in schizophrenia patients. Methods We used the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to assess the cognition of three groups of schizophrenia patients (318 on clozapine, 125 on risperidone, and 166 on typical antipsychotic drugs) and 399 healthy controls, and used the Positive and Negative Syndrome Scale to assess schizophrenia symptoms of patients. Results Patients taking typical antipsychotics scored higher on the immediate memory and delayed memory index than those taking clozapine or risperidone (allp< 0.01). Patients taking clozapine scored higher on the language subscale than those taking risperidone (p< 0.05). Multiple regression analysis showed that the drug type was identified as an independent contributor to the immediate memory, language, and delayed memory index of RBANS (allp< 0.05). Conclusions Patients taking typical antipsychotics have better memory than those taking clozapine or risperidone. Patients taking clozapine have better language function than those taking risperidone.
WOS关键词2ND-GENERATION ANTIPSYCHOTICS ; ATYPICAL ANTIPSYCHOTICS ; ACETYLCHOLINE-RECEPTORS ; CLOZAPINE ; RISPERIDONE ; MEMORY ; HALOPERIDOL ; IMPAIRMENT ; OLANZAPINE ; IMPACT
资助项目National Natural Science Foundation of China[81371477] ; CAS Pioneer Hundred Talents Program
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
语种英语
WOS记录号WOS:000571601700001
出版者WILEY
资助机构National Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program
源URL[http://ir.psych.ac.cn/handle/311026/32869]  
专题中国科学院心理研究所
通讯作者Yu, Liling; Zhang, Xiang Yang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China
3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Capital Med Univ, Coll Med Humanities, Dept Med Psychol, 10 Xitoutiao, Beijing, Peoples R China
6.Soochow Univ, Med Coll, Suzhou, Peoples R China
推荐引用方式
GB/T 7714		 Dong, Rui,Yuan, Lian,Yang, Yong,et al. Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2020:8.
APA Dong, Rui.,Yuan, Lian.,Yang, Yong.,Du, Xiang-Dong.,Jia, Qiufang.,...&Zhang, Xiang Yang.(2020).Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,8.
MLA Dong, Rui,et al."Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2020):8.

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来源：心理研究所

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