中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms

文献类型：期刊论文

作者Wang, Yong-ming3,4,5,6; Zhang, Yi-jing3,6; Cai, Xin-lu3,4,5,6; Yang, Han-xue3,6; Shan, Hai-di2; Cheung, Eric F. C.1; Chan, Raymond C. K.3,4,5,6
刊名ASIAN JOURNAL OF PSYCHIATRY
出版日期2020-08-01
卷号52页码:6
关键词Schizo-obsessive traits Schizotypal traits Obsessive-Compulsive Symptoms Grey matter volume White matter integrity
ISSN号1876-2018
DOI10.1016/j.ajp.2020.102096
通讯作者Chan, Raymond C. K.(rckchan@psych.ac.cn)
英文摘要Altered brain structures have been found in patients with schizo-obsessive disorder, schizophrenia and obsessive-compulsive disorder in previous studies. However, it is unclear whether similar brain changes are also found in individuals with high schizo-obsessive traits (SOT), high schizotypal traits (SCT) and obsessive-compulsive symptoms (OCS). We examined grey matter volume (GMV) and white matter integrity (WMI, including fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity) in 26 individuals with high SOT, 30 individuals with high SCT, 25 individuals with OCS and 30 individuals with low trait scores (LT) in this study. Correlation analysis between GMV, WMI, Schizotypal Personality Questionnaire (SPQ) scores and Obsessive-Compulsive Inventory-Revised (OCI-R) scores in the subclinical groups was also carried out. We found that the SOT group exhibited increased GMV at the right superior occipital gyrus and the left postcentral gyrus compared with the LT group. The SCT group exhibited increased GMV at the right precentral gyrus and the bilateral cuneus compared with the LT group, and decreased fractional anisotropy at the anterior corona radiata compared with the other three groups. The OCS group exhibited increased GMV at the left superior temporal gyrus and decreased GMV at the left pre-supplementary motor area compared with the LT group. These findings highlight specific brain changes in individuals with high SOT, high SCT and OCS, and may thus provide new insights into the neurobiological changes that occur in sub-clinical populations of these disorders.
WOS关键词ANTERIOR CORONA RADIATA ; BRAIN STRUCTURE ; BDNF GENE ; HIGH-RISK ; SCHIZOPHRENIA ; METAANALYSIS ; DISORDER ; ASSOCIATION ; SPECTRUM ; NEUROBIOLOGY
资助项目National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000573651300004
出版者ELSEVIER
资助机构National Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; Beijing Training Project for the Leading Talents in S T ; CAS Key Laboratory of Mental Health, Institute of Psychology
源URL[http://ir.psych.ac.cn/handle/311026/32878]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Castle Peak Hosp, Hong Kong, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, Sch Med, Shanghai, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100190, Peoples R China
6.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yong-ming,Zhang, Yi-jing,Cai, Xin-lu,et al. Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms[J]. ASIAN JOURNAL OF PSYCHIATRY,2020,52:6.
APA Wang, Yong-ming.,Zhang, Yi-jing.,Cai, Xin-lu.,Yang, Han-xue.,Shan, Hai-di.,...&Chan, Raymond C. K..(2020).Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms.ASIAN JOURNAL OF PSYCHIATRY,52,6.
MLA Wang, Yong-ming,et al."Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms".ASIAN JOURNAL OF PSYCHIATRY 52(2020):6.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。