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The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation

文献类型：期刊论文

作者Zhou, Hao1; Wang, Jiesi3; Zhang, Yu2; Shao, Feng1; Wang, Weiwen3
刊名FRONTIERS IN INTEGRATIVE NEUROSCIENCE
出版日期2020-09-04
卷号14页码:8
关键词CX3CR1 microglia schizophrenia social isolation prepulse inhibition
ISSN号1662-5145
DOI10.3389/fnint.2020.551676
通讯作者Shao, Feng(shaof@pku.edu.cn) ; Wang, Weiwen(wangww@psych.ac.cn)
英文摘要According to the microglial hypothesis of schizophrenia, the hyperactivation of microglia and the release of proinflammatory cytokines lead to neuronal loss, which is highly related to the onset of schizophrenia. Recent studies have demonstrated that fractalkine (CX3CL1) and its receptor CX3CR1 modulate the function of microglia. Thus, the present study aimed to determine whether microglial CX3CR1 plays a role in schizophrenia-related behaviors. A classical animal model of schizophrenia, social isolation (from postnatal days 21-56), was used to induce schizophrenia-related behaviors in C57BL/6J and CX3CR1(-/-)mice, and the expression of the microglial CX3CR1 protein was examined in several brain areas of the C57BL/6J mice by Western blot analysis. The results revealed that social isolation caused deficits in the prepulse inhibition (PPI) in the C57BL/6J mice but not in the CX3CR1(-/-) mice and increased locomotor activity in both the C57BL/6J mice and the CX3CR1(-/-) mice. Moreover, the CX3CR1 protein level was increased in the medial prefrontal cortex, nucleus accumbens, and hippocampus of the isolated C57BL/6J mice. These findings suggested that the function of microglia regulated by CX3CR1 might participate in schizophrenia-related behaviors.
WOS关键词BRAIN ; FRACTALKINE ; EXPRESSION ; RESILIENCE ; ACTIVATION ; CX(3)CR1 ; BLOOD ; GENE ; MICE
资助项目National Natural Science Foundation of China[31470988] ; National Natural Science Foundation of China[31771217] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000573643100001
出版者FRONTIERS MEDIA SA
资助机构National Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/32914]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Shao, Feng; Wang, Weiwen
作者单位1.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, Beijing, Peoples R China
2.Binzhou Med Univ, Sch Nursing, Yantai, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Hao,Wang, Jiesi,Zhang, Yu,et al. The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation[J]. FRONTIERS IN INTEGRATIVE NEUROSCIENCE,2020,14:8.
APA Zhou, Hao,Wang, Jiesi,Zhang, Yu,Shao, Feng,&Wang, Weiwen.(2020).The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation.FRONTIERS IN INTEGRATIVE NEUROSCIENCE,14,8.
MLA Zhou, Hao,et al."The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation".FRONTIERS IN INTEGRATIVE NEUROSCIENCE 14(2020):8.

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来源：心理研究所

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