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Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia

文献类型：期刊论文

作者He, Yuwen1,6; Wu, Shihao5; Chen, Cheng5; Fan, Lingzhong4; Li, Kaixin3; Wang, Gaohua5; Wang, Huiling5; Zhou, Yuan1,2,6
刊名NEUROSCIENCE
出版日期2020-10-15
卷号446页码:14-27
关键词prefrontal cortex schizophrenia Brief Assessment of Cognition in Schizophrenia dysconnectivity hypothesis resting-state functional connectivity
ISSN号0306-4522
DOI10.1016/j.neuroscience.2020.08.021
通讯作者Zhou, Yuan(zhouyuan@psych.ac.cn)
英文摘要Schizophrenia has prominent functional dysconnectivity, especially in the prefrontal cortex (PFC). However, it is unclear whether in the same group of patients with schizophrenia, PFC functional dysconnectivity appears in an organized manner or is stochastically located in different subregions. By investigating the restingstate functional connectivity (rsFC) of each PFC subregion from the Brainnetome atlas in 40 schizophrenia patients and 40 healthy subjects, we found 24 altered connections in schizophrenia, and the connections were divided into four categories by a clustering analysis: increased connections within the PFC, increased connections between the inferior PFC and the thalamus/striatum, reduced connections between the PFC and the motor control areas, and reduced connections between the orbital PFC and the emotional perception regions. In addition, the four categories of rsFC showed distinct cognitive engagement patterns. Our findings suggest that PFC subregions have specific functional dysconnectivity patterns in schizophrenia and may reflect heterogeneous symptoms and cognitive deficits in schizophrenia. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
WOS关键词NEUROLOGICAL SOFT SIGNS ; BRAIN NETWORKS ; PARANOID SCHIZOPHRENIA ; WORKING-MEMORY ; HEAD MOTION ; CONNECTIVITY ; FMRI ; DYSFUNCTION ; ASSOCIATION ; COGNITION
资助项目National Natural Science Foundation of China[81771473] ; National Natural Science Foundation of China[81371476] ; National Natural Science Foundation of China[91432302]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000577243000002
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/33006]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Zhou, Yuan
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Harbin Univ Sci & Technol, Harbin 150080, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 He, Yuwen,Wu, Shihao,Chen, Cheng,et al. Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia[J]. NEUROSCIENCE,2020,446:14-27.
APA He, Yuwen.,Wu, Shihao.,Chen, Cheng.,Fan, Lingzhong.,Li, Kaixin.,...&Zhou, Yuan.(2020).Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia.NEUROSCIENCE,446,14-27.
MLA He, Yuwen,et al."Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia".NEUROSCIENCE 446(2020):14-27.

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来源：心理研究所

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