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Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder

文献类型：期刊论文

作者Ma, Yue-Jiao1,7; Zhou, Yong-Jie2,5; Wang, Dong-Fang6; Li, Yi2,5; Wang, Dong-Mei3; Liu, Tie-Qiao7; Zhang, Xiang-Yang3,4
刊名FRONTIERS IN PSYCHIATRY
出版日期2020-09-30
卷号11页码:9
关键词major depressive disorder lipid suicide attempt clinical symptom first episode
ISSN号1664-0640
DOI10.3389/fpsyt.2020.543632
通讯作者Liu, Tie-Qiao(liutieqiao123@csu.edu.cn) ; Zhang, Xiang-Yang(zhangxy@psych.ac.cn)
英文摘要Several studies have reported a link between lipid disorders and suicidality. However, few studies have investigated the relationship between suicidal behavior and blood lipid profiles in patients with first-episode and drug-naive (FEDN) major depressive disorder (MDD). The main purpose of this study was to examine the relationship between plasma lipid profiles and suicide attempts in a large sample of FEDN MDD patients in the Chinese Han population, which has not been reported. A total of 1,718 MDD outpatients were recruited. Their clinical and demographic data as well as plasma lipid parameters were collected. We obtained suicide attempt data through interviews with patients and their family members. We rated the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) for all patients. The suicide attempt rate of MDD patients was 20.14%, of which 13.68% in the last month and 6.46% in the past. Further, compared with non-attempters, suicide attempters had significantly higher total levels of cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c), higher HAMA and HAMD scores, but significantly lower high-density lipoprotein cholesterol (HDL-c) levels. Logistic regression analysis showed that suicide attempts were correlated with higher TC, lower HDL-c, and higher HAMA and HAMD scores with the adjusted odds ratio (OR) of 1.35, 0.52,1.28, and 1.08, respectively (all p < 0.05). Our findings suggest that FEDN patients with MDD have a high rate of attempted suicide. In the early stage of MDD patients, certain blood lipid parameters and more severe symptoms of anxiety and depression are correlated with suicide attempts. However, due to the cross-sectional design of this study, it is impossible to draw a causal relationship between lipid profiles and suicide attempts. Moreover, an inverse correlation can also be considered, that is, high cholesterol may be the consequence of suicide attempts and depression.
WOS关键词LOW SERUM-CHOLESTEROL ; DENSITY-LIPOPROTEIN CHOLESTEROL ; RISK ; PREVALENCE ; MORTALITY ; BEHAVIOR ; LEPTIN
资助项目National Key R&D Program of China[2017YFC1310400] ; National Natural Science Foundation of China[81371465] ; National Natural Science Foundation of China[81671324] ; Fundamental Research Founds for the Central South University[105332 0183555]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000577561000001
出版者FRONTIERS MEDIA SA
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Fundamental Research Founds for the Central South University
源URL[http://ir.psych.ac.cn/handle/311026/33012]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Liu, Tie-Qiao; Zhang, Xiang-Yang
作者单位1.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, Mannheim, Germany
2.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Tongji Med Coll, Wuhan, Peoples R China
6.Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany
7.Cent South Univ, Chinese Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov,Xiangya, Chinese Natl Technol Inst Psychiat,Dept Psychiat, Changsha, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Yue-Jiao,Zhou, Yong-Jie,Wang, Dong-Fang,et al. Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder[J]. FRONTIERS IN PSYCHIATRY,2020,11:9.
APA Ma, Yue-Jiao.,Zhou, Yong-Jie.,Wang, Dong-Fang.,Li, Yi.,Wang, Dong-Mei.,...&Zhang, Xiang-Yang.(2020).Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder.FRONTIERS IN PSYCHIATRY,11,9.
MLA Ma, Yue-Jiao,et al."Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder".FRONTIERS IN PSYCHIATRY 11(2020):9.

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来源：心理研究所

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