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Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms

文献类型：期刊论文

作者Lang, XiaoE4; Wang, Dong Mei1,5; Du, Xiang Dong3; Jia, Qiu Fang3; Chen, Da Chun2; Xiu, Meihong2; Wang, Li1,5; Zhang, XiangYang1,5
刊名SCHIZOPHRENIA RESEARCH
出版日期2020-08-01
卷号222页码:291-296
关键词Superoxide dismutase Schizophrenia Never-treated first episode
ISSN号0920-9964
DOI10.1016/j.schres.2020.05.032
通讯作者Lang, XiaoE(langxiaoe@yeah.net) ; Wang, Dong Mei(wangdm@psych.ac.cn) ; Zhang, XiangYang(zhangxy@psych.ac.cn)
英文摘要Oxidative stress in excess may be engaged in the pathophysiological development of schizophrenia (SCZ). Previous research showed altered activity of superoxide dismutase (SOD) in patients suffering from SCZ, with inconsistent results. However, few studies have analyzed the relationship between SOD activity and psychopathological symptoms in never-treated first-episode (NTFE) patients with SCZ. The activities of manganese SOD (MnSOD) and total SOD were measured in a large sample of 166 NTFE patients with SCZ, and 133 healthy controls. The patients' symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS), as well as the depressive and cognitive factors originated from the PANSS five-factor model. NTFE patients had significantly higher activities of MnSOD and total SOD than healthy controls (both p < 0.01). Correlation analysis displayed a notably positive correlation between both MnSOD or total SOD activities and the PANSS depressive factor, as well as between MnSOD activity and the PANSS general psychopathology subscale score (all p < 0.05). Stepwise multiple regression analysis revealed that both MnSOD and total SOD were independent factors affecting PANSS depressive factor and PANSS general psychopathology subscale score. Our findings suggest that increased SOD activity may be associated with comorbid depressive symptoms in NTFE patients with SCZ. (c) 2020 Published by Elsevier B.V.
WOS关键词NEGATIVE SYNDROME SCALE ; OXIDATIVE STRESS ; ANTIOXIDANT DEFENSE ; DRUG-NAIVE ; ALA-9VAL POLYMORPHISM ; 5-FACTOR MODEL ; DAMAGE ; HALOPERIDOL ; CATALASE ; ENZYMES
资助项目Key Research Project in Shanxi Province[201803D31098] ; Wu Jieping Medical Foundation[320.6750.18336] ; National Key Research and Development Program of China[2017YFC1310405] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000579854800037
出版者ELSEVIER
资助机构Key Research Project in Shanxi Province ; Wu Jieping Medical Foundation ; National Key Research and Development Program of China ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health
源URL[http://ir.psych.ac.cn/handle/311026/33047]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Lang, XiaoE; Wang, Dong Mei; Zhang, XiangYang
作者单位1.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Beijing Huilongguan Hosp, Beijing, Peoples R China
3.Soodhow Univ, Suzhou Psychiat Hosp, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China
4.Shanxi Med Univ, Clin Med Coll 1, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Lang, XiaoE,Wang, Dong Mei,Du, Xiang Dong,et al. Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms[J]. SCHIZOPHRENIA RESEARCH,2020,222:291-296.
APA Lang, XiaoE.,Wang, Dong Mei.,Du, Xiang Dong.,Jia, Qiu Fang.,Chen, Da Chun.,...&Zhang, XiangYang.(2020).Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms.SCHIZOPHRENIA RESEARCH,222,291-296.
MLA Lang, XiaoE,et al."Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms".SCHIZOPHRENIA RESEARCH 222(2020):291-296.

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来源：心理研究所

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