The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease
文献类型：期刊论文
| 作者 | Ye, Zheng5 ; Zhang, Guanyu6,7; Zhang, Yingshuang1; Li, Shuaiqi2; Liu, Na1; Zhou, Xiaolin2,3; Xiao, Weizhong1; Munte, Thomas F.4
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| 刊名 | MOVEMENT DISORDERS
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| 出版日期 | 2020-10-24 |
| 页码 | 10 |
| 关键词 | fMRI Parkinson&apos s disease sequential working memory subthalamic nucleus |
| ISSN号 | 0885-3185 |
| DOI | 10.1002/mds.28344 |
| 通讯作者 | Ye, Zheng(yez@ion.ac.cn) ; Zhang, Yingshuang(zhangys0317@126.com) ; Munte, Thomas F.(thomas.muente@neuro.uni-luebeck.de) |
| 英文摘要 | Background Deficits in maintaining and manipulating sequential information online can occur even in patients with mild Parkinson's disease. The subthalamic nucleus may play a modulatory role in the neural system for sequential working memory, which also includes the lateral prefrontal cortex. Objectives The objective of this study was to investigate neural markers of sequential working memory deficits in patients with de novo Parkinson's disease. Methods A total of 50 patients with de novo Parkinson's disease and 50 healthy controls completed a digit ordering task during functional magnetic resonance imaging scanning. The task separated the maintenance ("pure recall") and manipulation of sequences ("reorder & recall" vs. "pure recall"). Results In healthy controls, individual participants' task accuracy was predicted by the regional activation and functional connectivity of the subthalamic nucleus. Healthy participants who showed lower subthalamic nucleus activation and stronger subthalamic nucleus connectivity with the putamen performed more accurately in maintaining sequences ("pure recall"). Healthy participants who showed greater ordering-related subthalamic nucleus activation change exhibited smaller accuracy costs in manipulating sequences ("reorder & recall" vs. "pure recall"). Patients performed less accurately than healthy controls, especially in "reorder & recall" trials, accompanied by an overactivation in the subthalamic nucleus and a loss of synchrony between the subthalamic nucleus and putamen. Individual patients' task accuracy was predicted only by the subthalamic nucleus connectivity. The contribution of the subthalamic nucleus activation or activation change was absent. We observed no change in the lateral prefrontal cortex. Conclusions The overactivation and weakened functional connectivity of the subthalamic nucleus are the neural markers of sequential working memory deficits in de novo Parkinson's disease. (c) 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC. on behalf of International Parkinson and Movement Disorder Society |
| WOS关键词 | SHORT-TERM-MEMORY ; BRAIN-STIMULATION ; TEMPORAL-ORDER ; BASAL GANGLIA ; SERIAL ORDER ; DOPAMINE ; VALIDITY ; MODEL ; MOTOR ; STN |
| 资助项目 | National Natural Science Foundation of China[31771216] ; National Natural Science Foundation of China[31961133025] ; National Natural Science Foundation of China[31630034] ; German Research Foundation[SFB TR134 C1] ; Alexander von Humboldt Foundation |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000581795700001 |
| 出版者 | WILEY |
| 资助机构 | National Natural Science Foundation of China ; German Research Foundation ; Alexander von Humboldt Foundation |
| 源URL | [http://ir.psych.ac.cn/handle/311026/33056]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 通讯作者 | Ye, Zheng; Zhang, Yingshuang; Munte, Thomas F. |
| 作者单位 | 1.Peking Univ, Hosp 3, Dept Neurol, North Garden Rd 49, Beijing 100191, Peoples R China 2.Peking Univ, Sch Psychol & Cognit Sci, Ctr Brain & Cognit Sci, Beijing, Peoples R China 3.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China 4.Univ Lubeck, Dept Neurol, Ratzeburger Allee 160, D-23538 Lubeck, Germany 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Key Lab Primate Neurobiol, Inst Neurosci, Shanghai, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Zheng,Zhang, Guanyu,Zhang, Yingshuang,et al. The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease[J]. MOVEMENT DISORDERS,2020:10. |
| APA | Ye, Zheng.,Zhang, Guanyu.,Zhang, Yingshuang.,Li, Shuaiqi.,Liu, Na.,...&Munte, Thomas F..(2020).The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease.MOVEMENT DISORDERS,10. |
| MLA | Ye, Zheng,et al."The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease".MOVEMENT DISORDERS (2020):10. |
入库方式： OAI收割
来源：心理研究所
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