The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study
文献类型：期刊论文
| 作者 | Hua, Wei1; Hou, Jianhua1,2; Jiang, Taiyi1; Su, Bin1,2; Fu, Jiangning3; Sun, Runsong4; Chang, Biru5; Xia, Wei1; Wu, Hao1,2; Zhang, Tong1,2 |
| 刊名 | FRONTIERS IN CARDIOVASCULAR MEDICINE
 |
| 出版日期 | 2020-10-19 |
| 卷号 | 7页码:11 |
| 关键词 | cardiovascular risk cognition longitudinal study older adult national representative data set |
| ISSN号 | 2297-055X |
| DOI | 10.3389/fcvm.2020.560947 |
| 通讯作者 | Guo, Caiping(gcpdt001@126.com) ; Wang, Wen(Youansuid2020@hotmail.com) |
| 英文摘要 | Objective: China has the largest population living with dementia, causing a tremendous burden on the aging society. Cardiovascular disease (CVD) may trigger a cascade of pathologies associated with cognitive aging. We aim to investigate the association between cardiovascular risk (CVR) factors and cognitive function in the nationally representative cohort in China. Methods: Participants were recruited from 150 counties in 28 provinces via a four-stage sampling method. The outcomes included several cognitive tasks. The independent variable was a composite score of cardiovascular risk calculated from sex-specific equations. We fitted the time-lagged regression to model the association between CVR and cognition. Besides, we performed cross-group analyses to test for model invariance across sex and age. We thus constrained path coefficients to be equal across each grouping variable (e.g., sex) and compared the fit of this constrained model with an unconstrained model in which the path coefficients were allowed to vary by group. Results: A total of 3,799 participants were included in the final analyses. We found that the CVR had a negative linear association with global cognition (beta = -0.1, p < 0.01). Additionally, CVR had inverse linear associations with domain-specific measurements of memory and learning, calculation, orientation, and visual-spatial ability (all values of p < 0.01). Regarding sex and age moderation, males had a more pronounced association between higher CVR and worse general cognition, immediate recall, orientation, calculation, and visual-spatial ability (all values of p < 0.0001). In contrast, females exhibited a slightly larger negative association in delayed recall. Older participants (>65 years old) had a more pronounced association between higher CVR and worse calculation ability (p = 0.003). Conclusion: CVD are risk factors for lower global cognition and cognitive subdomains in middle-aged and older adults in China. |
| WOS关键词 | NORTHERN MANHATTAN ; SEX-DIFFERENCES ; DECLINE ; HYPERTENSION ; PREVALENCE ; DEMENTIA ; PROFILE ; TRAJECTORIES ; POPULATION ; MEMORY |
| 资助项目 | National 13th 5-Year Grand Program on Key Infectious Disease Control[2018ZX10715-005-002-002] ; National 13th 5-Year Grand Program on Key Infectious Disease Control[2017ZX10202101-001-004] ; National 13th 5-Year Grand Program on Key Infectious Disease Control[2017ZX10202101-004-001] ; National 13th 5-Year Grand Program on Key Infectious Disease Control[2018ZX10301-407-005] ; National 13th 5-Year Grand Program on Key Infectious Disease Control[2018ZX10302103-001-003] ; Beijing Municipal of Science and Technology Major Project[D161100000416003] ; Beijing Municipal of Science and Technology Major Project[D161100000416005] ; Key Laboratory of Capital Medical University[BJYAHKF2017002] ; Beijing Key Laboratory for HIV/AIDS Research[BZ0089] |
| WOS研究方向 | Cardiovascular System & Cardiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000583254800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National 13th 5-Year Grand Program on Key Infectious Disease Control ; Beijing Municipal of Science and Technology Major Project ; Key Laboratory of Capital Medical University ; Beijing Key Laboratory for HIV/AIDS Research |
| 源URL | [http://ir.psych.ac.cn/handle/311026/33381]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 通讯作者 | Guo, Caiping; Wang, Wen |
| 作者单位 | 1.Capital Med Univ, Beijing Youan Hosp, Ctr Infect Dis, Beijing, Peoples R China 2.Beijing Key Lab HIV AIDS Res, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 4.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 5.Shanghai Normal Univ, Res Inst Int & Comparat Educ, Dept Psychol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hua, Wei,Hou, Jianhua,Jiang, Taiyi,et al. The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study[J]. FRONTIERS IN CARDIOVASCULAR MEDICINE,2020,7:11. |
| APA | Hua, Wei.,Hou, Jianhua.,Jiang, Taiyi.,Su, Bin.,Fu, Jiangning.,...&Wang, Wen.(2020).The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study.FRONTIERS IN CARDIOVASCULAR MEDICINE,7,11. |
| MLA | Hua, Wei,et al."The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study".FRONTIERS IN CARDIOVASCULAR MEDICINE 7(2020):11. |
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来源：心理研究所
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