Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls
文献类型：期刊论文
| 作者 | Tian, Yang2,3; Wang, Dongmei2,3 ; Wei, Gaoxia2,3; Wang, Jiesi2,3; Zhou, Huixia2,3; Xu, Hang2,3; Dai, Qilong2,3; Xiu, Meihong1; Chen, Dachun1; Wang, Li2,3
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| 刊名 | PSYCHOPHARMACOLOGY
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| 出版日期 | 2020-11-25 |
| 页码 | 9 |
| ISSN号 | 0033-3158 |
| 关键词 | First-episode drug-naive with schizophrenia Clinical symptom Obesity Body mass index |
| DOI | 10.1007/s00213-020-05727-1 |
| 通讯作者 | Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Objective People with schizophrenia exhibit a high obesity rate. However, little is known about the prevalence of obesity and its relationship with clinical symptoms and metabolic indicators in first-episode drug-naive (FEDN) schizophrenia. Methods Demographic and lipid parameters were gathered from 297 FEDN schizophrenia and 325 healthy controls. The patients' symptomatology was evaluated by the Positive and Negative Syndrome Scale (PANSS). Results The obesity rate of FEDN patients was 10.77%, similar to that of controls (10.5%). The prevalence of overweight plus obesity of patients was 44.8%, significantly higher than that of controls (36.6%). Compared with non-obese patients, obese patients had higher levels of cholesterol (4.81 +/- 0.93 vs 4.22 +/- 1.00 mmol/L), triglyceride (0.27 +/- 0.21 vs 0.14 +/- 0.24 mg/dL), low-density lipoprotein (0.48 +/- 0.12 vs 0.40 +/- 0.12 mg/dL), greater ratio of triglyceride/high-density lipoprotein (2.01 +/- 1.23 vs 1.44 +/- 1.26), and higher PANSS positive symptom subscale score (29.81 +/- 6.29 vs 27.05 +/- 6.15), general psychopathology subscale score (70.75 +/- 11.74 vs 66.87 +/- 11.37), and total score (149.81 +/- 21.08 vs 140.64 +/- 21.58), but lower high-density lipoprotein level (1.09 +/- 0.21 vs 1.27 +/- 0.34 mg/dL) (all p < 0.05). Correlation analysis revealed that body mass index (BMI) was positively correlated with triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, triglyceride/high-density lipoprotein ratio, PANSS positive symptoms, general psychopathology, and total scores (all p < 0.05, r = 0.124 similar to 0.335). Multiple regression analysis confirmed that PANSS positive symptoms, total score, and cholesterol level were significantly associated with BMI (all p < 0.05, beta: 0.126-0.162). Conclusion There was no significant difference in the prevalence of obesity between FEDN patients and the control group. Moreover, BMI was positively associated with positive symptom severity in FEDN patients. |
| WOS关键词 | INDUCED WEIGHT-GAIN ; DRUG-FREE PATIENTS ; BODY-MASS INDEX ; INSULIN-RESISTANCE ; CHINESE PATIENTS ; SELF-ESTEEM ; FOOD-INTAKE ; NAIVE ; DYSLIPIDEMIA ; MECHANISMS |
| 资助项目 | CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China[81371477] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000592578300004 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/33442]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang Yang |
| 作者单位 | 1.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Yang,Wang, Dongmei,Wei, Gaoxia,et al. Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls[J]. PSYCHOPHARMACOLOGY,2020:9. |
| APA | Tian, Yang.,Wang, Dongmei.,Wei, Gaoxia.,Wang, Jiesi.,Zhou, Huixia.,...&Zhang, Xiang Yang.(2020).Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls.PSYCHOPHARMACOLOGY,9. |
| MLA | Tian, Yang,et al."Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls".PSYCHOPHARMACOLOGY (2020):9. |
入库方式： OAI收割
来源：心理研究所
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