Cognitive Enhancing Effect of High-Frequency Neuronavigated rTMS in Chronic Schizophrenia Patients With Predominant Negative Symptoms: A Double-Blind Controlled 32-Week Follow-up Study
文献类型：期刊论文
| 作者 | Xiu, Mei Hong1; Guan, Heng Yong2; Zhao, Jian Min2; Wang, Ke Qiang2; Pan, Yan Fen2; Su, Xiu Ru2; Wang, Yu Hong2; Guo, Jin Ming2; Jiang, Long2; Liu, Hong Yu2 |
| 刊名 | SCHIZOPHRENIA BULLETIN
 |
| 出版日期 | 2020-09-01 |
| 卷号 | 46期号:5页码:1219-1230 |
| ISSN号 | 0586-7614 |
| 关键词 | schizophrenia cognition rTMS randomized controlled trial immediate memory |
| DOI | 10.1093/schbul/sbaa035 |
| 通讯作者 | Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Accumulating studies have shown that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) may improve cognitive dysfunction of the patients with schizophrenia (SCZ), but with inconsistent results. The present study aims to assess the efficacy of different frequencies of neuronavigated rTMS in ameliorating cognitive impairments and alleviating the psychotic symptoms. A total of 120 patients were randomly assigned to 3 groups: 20 Hz rTMS (n = 40), 10 Hz rTMS (n = 40), or sham stimulation (n = 40) for 8 weeks, and then followed up at week 32. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was performed to assess the cognitive functions of the patients at baseline, at the end of week 8, and week 32 follow-up. Psychotic symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS) at baseline and at the end of week 2, week 4, week 6, week 8, and week 32 follow-up. Our results demonstrated that 20 Hz rTMS treatment produced an effective therapeutic benefit on immediate memory of patients with chronic SCZ at week 8, but not in the 10 Hz group. Interestingly, both 10 Hz and 20 Hz rTMS treatments produced delayed effects on cognitive functions at the 6-month follow-up. Moreover, in both 10 Hz rTMS and 20 Hz rTMS, the improvements in RBANS total score were positively correlated with the reduction of PANSS positive subscore at the 6-month follow-up. Stepwise regression analysis identified that the visuospatial/constructional index, immediate memory index, and prolactin at baseline were predictors for the improvement of cognitive impairments in the patients. Our results suggest that add-on HF rTMS could be an effective treatment for cognitive impairments in patients with chronic SCZ, with a delayed effect. |
| WOS关键词 | TRANSCRANIAL MAGNETIC STIMULATION ; DORSOLATERAL PREFRONTAL CORTEX ; BRAIN-STIMULATION ; METAANALYSIS ; EFFICACY ; REMEDIATION ; PROLACTIN ; DOPAMINE ; TMS |
| 资助项目 | Scientific and Technological Program of Hebei[20150593] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS |
| WOS记录号 | WOS:000593174100024 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/33448]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang Yang |
| 作者单位 | 1.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 2.Hebei Prov Rong Jun Hosp, Dept Psychiat, Baoding, Peoples R China 3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiu, Mei Hong,Guan, Heng Yong,Zhao, Jian Min,et al. Cognitive Enhancing Effect of High-Frequency Neuronavigated rTMS in Chronic Schizophrenia Patients With Predominant Negative Symptoms: A Double-Blind Controlled 32-Week Follow-up Study[J]. SCHIZOPHRENIA BULLETIN,2020,46(5):1219-1230. |
| APA | Xiu, Mei Hong.,Guan, Heng Yong.,Zhao, Jian Min.,Wang, Ke Qiang.,Pan, Yan Fen.,...&Zhang, Xiang Yang.(2020).Cognitive Enhancing Effect of High-Frequency Neuronavigated rTMS in Chronic Schizophrenia Patients With Predominant Negative Symptoms: A Double-Blind Controlled 32-Week Follow-up Study.SCHIZOPHRENIA BULLETIN,46(5),1219-1230. |
| MLA | Xiu, Mei Hong,et al."Cognitive Enhancing Effect of High-Frequency Neuronavigated rTMS in Chronic Schizophrenia Patients With Predominant Negative Symptoms: A Double-Blind Controlled 32-Week Follow-up Study".SCHIZOPHRENIA BULLETIN 46.5(2020):1219-1230. |
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来源：心理研究所
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