Sex-specific association between peripheral superoxide dismutase, BDNF and cognitive impairment in drug-naive first episode patients with schizophrenia
文献类型：期刊论文
| 作者 | Qu, Miao2; Wang, Jun1 ; Chen, Chun1; Chen, Song1; Xiu, Mei Hong1; Zhang, Xiang Yang3,4
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| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
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| 出版日期 | 2020-11-20 |
| 卷号 | 160页码:887-893 |
| 关键词 | Schizophrenia BDNF Superoxide dismutase Sex difference Cognitive function |
| ISSN号 | 0891-5849 |
| DOI | 10.1016/j.freeradbiomed.2020.09.014 |
| 通讯作者 | Xiu, Mei Hong(xiumeihong97@163.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Patients with schizophrenia (SCZ) have cognitive impairments across several domains. Cognition decline is related to the complex interrelationship between brain-derived neurotrophic factor (BDNF) and redox system imbalance. However, the effect of sex on cognitive impairment and biomarkers has not been fully studied in patients with drug-naive first episode (DNFE) SCZ. 327 DNFE SCZ patients and 391 healthy controls were recruited, and the levels of BDNF and malondialdehyde (MDA) and the activities of total SOD, Mn-SOD, CuZn-SOD enzymes were measured. Cognitive function was measured by using the Repeatable Battery for the Assessment of Neuropsychological status (RBANS) and clinical symptoms by the Positive and Negative Syndrome Scale (PANSS). Patients performed worse on most cognitive tasks than controls, but there was no significant sex difference in cognitive function between patients and controls. Further analysis showed that a sex difference in MDA was found in controls rather than patients, indicating that MDA levels in men were higher than those in women in controls. Moreover, the Mn-SOD was significantly correlated with attention, language and RBANS total scores only in male patients. Multiple linear regression analysis showed that the interaction between BDNF and Mn-SOD or SOD was associated with RBANS language index score in male patients. Our results suggest that the interrelationship of BDNF with antioxidant mechanisms may contribute to the pathological mechanisms underlying cognitive deficits only in male DNFE patients with SCZ, but not in female patients. |
| WOS关键词 | NEGATIVE SYNDROME SCALE ; OXIDATIVE STRESS ; GENDER-DIFFERENCE ; FATTY-ACID ; PLASMA ; BRAIN ; MITOCHONDRIA ; TESTOSTERONE ; POLYMORPHISM ; SYMPTOMS |
| 资助项目 | National Natural Science Foundation of China[81973759] ; National Natural Science Foundation of China[81000509] ; National Natural Science Foundation of China[10400633210001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000595084100003 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://ir.psych.ac.cn/handle/311026/33451]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Xiu, Mei Hong; Zhang, Xiang Yang |
| 作者单位 | 1.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 2.Capital Med Univ, Neurol Dept, Xuan Wu Hosp, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qu, Miao,Wang, Jun,Chen, Chun,et al. Sex-specific association between peripheral superoxide dismutase, BDNF and cognitive impairment in drug-naive first episode patients with schizophrenia[J]. FREE RADICAL BIOLOGY AND MEDICINE,2020,160:887-893. |
| APA | Qu, Miao,Wang, Jun,Chen, Chun,Chen, Song,Xiu, Mei Hong,&Zhang, Xiang Yang.(2020).Sex-specific association between peripheral superoxide dismutase, BDNF and cognitive impairment in drug-naive first episode patients with schizophrenia.FREE RADICAL BIOLOGY AND MEDICINE,160,887-893. |
| MLA | Qu, Miao,et al."Sex-specific association between peripheral superoxide dismutase, BDNF and cognitive impairment in drug-naive first episode patients with schizophrenia".FREE RADICAL BIOLOGY AND MEDICINE 160(2020):887-893. |
入库方式： OAI收割
来源：心理研究所
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