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Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits

文献类型：期刊论文

作者Wang, Yong-ming1,2,4,5; Cai, Xin-lu1,2,4,5; Zhou, Han-yu1,4; Zhang, Rui-ting1,4; Zhang, Yi-jing1,4; Wang, Yan-yu1,4; Cheung, Eric F. C.3; Chan, Raymond C. K.1,2,4,5
刊名PSYCHIATRY RESEARCH-NEUROIMAGING
出版日期2020-11-30
卷号305页码:9
ISSN号0925-4927
关键词Schizo-obsessive traits Schizotypal traits Obsessive-compulsive traits Functional connectivity Default mode network
DOI10.1016/j.pscychresns.2020.111170
通讯作者Chan, Raymond C. K.(rckchan@psych.ac.cn)
英文摘要In this study, we examined differences in resting-state functional connectivity between sub-regions of the Default Mode Network (DMN) and whole brain voxels in 22 individuals with high schizo-obsessive traits (SOT), 30 with high schizotypal traits (SCT) alone, 20 with high obsessive-compulsive traits (OCT) alone and 30 with low trait scores (LT). We found that the SOT group showed the most reduced functional connectivity within the DMN compared with the other groups. The SOT group also showed increased connectivity between the DMN and the Salience Network, and between the DMN and the Auditory Network compared with the LT group. The SCT group exhibited increased connectivity between the DMN and the Salience Network, and between the DMN and the Executive Control Network (ECN) compared with the LT group. The OCT group exhibited decreased connectivity within the DMN, between the DMN and the Salience Network, and between the DMN and the ECN compared with the LT group. These findings highlight different changes in DMN-related functional connectivity associated with high SOT, SCT and OCT traits and may provide insight into the dysfunctional brain networks in the early stage of schizophrenia spectrum disorders.
WOS关键词RESTING-STATE ; PERSONALITY-TRAITS ; SALIENCE NETWORK ; SCHIZOPHRENIA ; DISORDER ; PSYCHOSIS ; SYMPTOMS ; DISINTEGRATION ; SYMPTOMATOLOGY ; DYSCONNECTION
资助项目National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Chinese Academy of Science[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者ELSEVIER IRELAND LTD
WOS记录号WOS:000581591900005
源URL[http://ir.psych.ac.cn/handle/311026/33467]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100190, Peoples R China
3.Castle Peak Hosp, Hong Kong, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yong-ming,Cai, Xin-lu,Zhou, Han-yu,et al. Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2020,305:9.
APA Wang, Yong-ming.,Cai, Xin-lu.,Zhou, Han-yu.,Zhang, Rui-ting.,Zhang, Yi-jing.,...&Chan, Raymond C. K..(2020).Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits.PSYCHIATRY RESEARCH-NEUROIMAGING,305,9.
MLA Wang, Yong-ming,et al."Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits".PSYCHIATRY RESEARCH-NEUROIMAGING 305(2020):9.

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来源：心理研究所

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