The association between anxiety and esophageal cancer: A nationwide population-based study
文献类型：期刊论文
| 作者 | Zhu, Juan1; Zhou, Yueyue2; Ma, Shanrui1; Chen, Ru1; Xie, Shuanghua1; Liu, Zhengkui2 ; Li, Xinqing1; Wei, Wenqiang1
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| 刊名 | PSYCHO-ONCOLOGY
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| 出版日期 | 2020-11-03 |
| 页码 | 10 |
| ISSN号 | 1057-9249 |
| 关键词 | endoscopy esophageal cancer GAD gastroscopy generalized anxiety disorder health‐ related quality of life high‐ risk regions screening |
| DOI | 10.1002/pon.5580 |
| 通讯作者 | Wei, Wenqiang(weiwq@cicams.ac.cn) |
| 英文摘要 | Objective Research on generalized anxiety disorder (GAD) and its association with esophageal cancer (EC) is sparse. The study aimed to explore the association between GAD and EC. Methods A multicenter, population-based study in high-risk regions for EC (ECHRRs) was conducted from 2017 to 2019. All participants received free endoscopy screening. If the esophageal endoscopy results were suspicious, the pathological biopsy was performed to confirm normal, esophagitis, low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN), and EC. Information on participants' exposure to risk factors was collected. GAD was assessed with Generalized Anxiety Disorder Scale-7. Results With esophageal endoscopy, 25,650 participants in ECHRRs were examined, 9586 of whom were suspicious and confirmed by esophageal pathology. The detection rate of EC and precancerous lesions was 6.83% (1751/25,650), with 1377 LGIN (5.37%), 272 HGIN (1.06%), and 102 EC (0.40%) cases. The overall mean GAD score (95% CI) and prevalence among 25,650 participants with endoscopy were 1.96 (1.93-1.99) and 16.90%, respectively. The mean GAD score and prevalence among 9586 participants with pathology were 1.96 (1.91-2.02) and 17.98%, respectively. The mean GAD scores of patients confirmed with normal, esophagitis, LGIN, HGIN, and EC were 1.73 (1.62-1.85), 1.91 (1.85-1.97), 1.94 (1.80-2.08), 3.98 (3.73-4.23). and 2.97 (2.49-3.45), respectively (p < 0.001). The corresponding prevalence of GAD were 5.21%, 18.72%, 17.72%, 43.75%, and 36.27%, respectively (p < 0.001). The age- and gender-adjusted odds ratios (ORs) between GAD and each esophageal lesion type were 1.02 (0.99-1.04), 1.01 (0.98-1.04), 1.27 (1.21-1.33), and 1.16 (1.08-1.24), respectively. The ORs (95% CIs) of the positive associations were 1.08 (1.05-1.12), 1.03 (0.99-1.07), 1.35 (1.29-1.42), and 1.19 (1.10-1.29) after further adjustment for potential confounders (all p < 0.001). Sensitivity analysis showed that the positive association persisted. Conclusions GAD was significantly higher in patients with EC and precancerous lesions. Focusing on and alleviating anxiety in high-risk groups (including patients with HGIN and EC) may be an effective strategy for EC prevention and control. Further prospective studies are warranted to validate the results. |
| WOS关键词 | TERM-FOLLOW-UP ; MENTAL-DISORDERS ; CHINA ; DEPRESSION ; PREVALENCE ; MORTALITY ; PEOPLE ; RISK ; METAANALYSIS ; VALIDATION |
| 资助项目 | National Key Research and Development Program (Precision Medicine Research)[2016YFC0901400] ; National Key Research and Development Program (Precision Medicine Research)[2016YFC0901404] |
| WOS研究方向 | Oncology ; Psychology ; Biomedical Social Sciences |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000584004100001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/33499]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wei, Wenqiang |
| 作者单位 | 1.Chinese Acad Med Sci & Peking Union Med Coll, CAMS & PUMC, Natl Clin Res Ctr Canc, Canc Registry Off,Natl Canc Ctr,Canc Hosp, 17 Panjiayuan Nanli, Beijing 100021, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Juan,Zhou, Yueyue,Ma, Shanrui,et al. The association between anxiety and esophageal cancer: A nationwide population-based study[J]. PSYCHO-ONCOLOGY,2020:10. |
| APA | Zhu, Juan.,Zhou, Yueyue.,Ma, Shanrui.,Chen, Ru.,Xie, Shuanghua.,...&Wei, Wenqiang.(2020).The association between anxiety and esophageal cancer: A nationwide population-based study.PSYCHO-ONCOLOGY,10. |
| MLA | Zhu, Juan,et al."The association between anxiety and esophageal cancer: A nationwide population-based study".PSYCHO-ONCOLOGY (2020):10. |
入库方式： OAI收割
来源：心理研究所
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