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Supraspinal neural mechanisms of the analgesic effect produced by transcutaneous electrical nerve stimulation

文献类型：期刊论文

作者Bi, Yanzhi1,4; Wei, Zhaoxing3,4; Kong, Yazhuo3,4; Hu, Li1,2,4
刊名BRAIN STRUCTURE & FUNCTION
出版日期2020-11-24
页码12
关键词Transcutaneous electrical nerve stimulation (TENS) Pain Functional magnetic resonance imaging (fMRI) Analgesic effect Subnucleus reticularis dorsalis (SRD) Rostral ventromedial medulla (RVM)
ISSN号1863-2653
DOI10.1007/s00429-020-02173-9
通讯作者Hu, Li(huli@psych.ac.cn)
英文摘要Although the analgesic effects of conventional transcutaneous electrical nerve stimulation (TENS) and acupuncture-like TENS are evident, their respective neural mechanisms in humans remain controversial. To elucidate and compare the supraspinal neural mechanisms of the analgesic effects produced by conventional TENS (high frequency and low intensity) and acupuncture-like TENS (low frequency and high intensity), we employed a between-subject sham-controlled experimental design with conventional, acupuncture-like, and sham TENS in 60 healthy human volunteers. In addition to assessing the TENS-induced changes of subjective ratings of perceived pain, we examined the TENS associated brainstem activities (fractional amplitude of low frequency fluctuations, fALFF) and their corresponding resting state functional connectivity (RSFC) with higher-order brain areas using functional magnetic resonance imaging. The analgesic effect of conventional TENS was only detected in the forearm that received TENS, coupled with decreased pons activity and RSFC between pons and contralateral primary somatosensory cortex. In contrast, acupuncture-like TENS produced a spatially diffuse analgesic effect, coupled with increased activities in both subnucleus reticularis dorsalis (SRD) and rostral ventromedial medulla (RVM), and decreased RSFC between SRD and medial frontal regions as well as between SRD and lingual gyrus. To sum up, our data demonstrated that conventional TENS and acupuncture-like TENS have different analgesic effects, which are mediated by different supraspinal neural mechanisms.
WOS关键词CONDITIONED PAIN MODULATION ; NOXIOUS INHIBITORY CONTROLS ; SUBNUCLEUS-RETICULARIS-DORSALIS ; RESTING-STATE ; OPIOID RECEPTORS ; LOW-FREQUENCY ; INVOLVEMENT ; FMRI ; PATHWAYS ; PREVENTS
资助项目National Natural Science Foundation of China[31800926] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[31671141] ; China Postdoctoral Science Foundation[2018M640191] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y8CX351005] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2018ZG01] ; Magnetic Resonance Imaging Research Center, Institute of Psychology, CAS
WOS研究方向Anatomy & Morphology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000592155600001
出版者SPRINGER HEIDELBERG
源URL[http://ir.psych.ac.cn/handle/311026/33516]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Hu, Li
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Guangzhou Med Univ, Dept Pain Management, State Key Clin Specialty Pain Med, Affiliated Hosp 2, Guangzhou, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Bi, Yanzhi,Wei, Zhaoxing,Kong, Yazhuo,et al. Supraspinal neural mechanisms of the analgesic effect produced by transcutaneous electrical nerve stimulation[J]. BRAIN STRUCTURE & FUNCTION,2020:12.
APA Bi, Yanzhi,Wei, Zhaoxing,Kong, Yazhuo,&Hu, Li.(2020).Supraspinal neural mechanisms of the analgesic effect produced by transcutaneous electrical nerve stimulation.BRAIN STRUCTURE & FUNCTION,12.
MLA Bi, Yanzhi,et al."Supraspinal neural mechanisms of the analgesic effect produced by transcutaneous electrical nerve stimulation".BRAIN STRUCTURE & FUNCTION (2020):12.

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来源：心理研究所

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