Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia
文献类型：期刊论文
| 作者 | Rollins, Colleen P. E.2; Garrison, Jane R.13; Arribas, Maite11,12; Seyedsalehi, Aida10,11; Li, Zhi9; Chan, Raymond C. K.9 ; Yang, Junwei8; Wang, Duo8; Lio, Pietro8; Yan, Chao7
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| 刊名 | TRANSLATIONAL PSYCHIATRY
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| 出版日期 | 2020-11-06 |
| 卷号 | 10期号:1页码:14 |
| ISSN号 | 2158-3188 |
| DOI | 10.1038/s41398-020-01075-y |
| 通讯作者 | Rollins, Colleen P. E.(cper2@cam.ac.uk) |
| 英文摘要 | All perception is a construction of the brain from sensory input. Our first perceptions begin during gestation, making fetal brain development fundamental to how we experience a diverse world. Hallucinations are percepts without origin in physical reality that occur in health and disease. Despite longstanding research on the brain structures supporting hallucinations and on perinatal contributions to the pathophysiology of schizophrenia, what links these two distinct lines of research remains unclear. Sulcal patterns derived from structural magnetic resonance (MR) images can provide a proxy in adulthood for early brain development. We studied two independent datasets of patients with schizophrenia who underwent clinical assessment and 3T MR imaging from the United Kingdom and Shanghai, China (n=181 combined) and 63 healthy controls from Shanghai. Participants were stratified into those with (n=79 UK; n=22 Shanghai) and without (n=43 UK; n=37 Shanghai) hallucinations from the PANSS P3 scores for hallucinatory behaviour. We quantified the length, depth, and asymmetry indices of the paracingulate and superior temporal sulci (PCS, STS), which have previously been associated with hallucinations in schizophrenia, and constructed cortical folding covariance matrices organized by large-scale functional networks. In both ethnic groups, we demonstrated a significantly shorter left PCS in patients with hallucinations compared to those without, and to healthy controls. Reduced PCS length and STS depth corresponded to focal deviations in their geometry and to significantly increased covariance within and between areas of the salience and auditory networks. The discovery of neurodevelopmental alterations contributing to hallucinations establishes testable models for these enigmatic, sometimes highly distressing, perceptions and provides mechanistic insight into the pathological consequences of prenatal origins. |
| WOS关键词 | ANTERIOR CINGULATE CORTEX ; AUDITORY HALLUCINATIONS ; STRUCTURAL COVARIANCE ; PARACINGULATE SULCUS ; BRAIN ; REALITY ; GYRIFICATION ; ASYMMETRY ; RISK ; ABNORMALITIES |
| 资助项目 | Gates Cambridge ; National Key Research and Development Program[2016YFC0906402] ; National Science Fund China[81571317] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; MRC Clinical Research Infrastructure Award[MR/M009041/1] ; NIHR Cambridge Biomedical Research Centre |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000591309300008 |
| 出版者 | SPRINGERNATURE |
| 源URL | [http://ir.psych.ac.cn/handle/311026/33525]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Rollins, Colleen P. E. |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China 2.Univ Cambridge, Dept Psychiat, Cambridge, England 3.Univ Manchester, Neurosci & Psychiat Unit, Manchester, Lancs, England 4.Univ Birmingham, Inst Mental Hlth, Birmingham, W Midlands, England 5.Univ Paris, IPNP, INSERM, F-75005 Paris, France 6.Univ Paris, LaPsyDE, CNRS, F-75005 Paris, France 7.East China Normal Univ, Key Lab Brain Funct Genom MOE & STCSM, Sch Psychol & Cognit Sci, Shanghai, Peoples R China 8.Univ Cambridge, Dept Comp Sci & Technol, Cambridge, England 9.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 10.Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England |
| 推荐引用方式 GB/T 7714 | Rollins, Colleen P. E.,Garrison, Jane R.,Arribas, Maite,et al. Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1):14. |
| APA | Rollins, Colleen P. E..,Garrison, Jane R..,Arribas, Maite.,Seyedsalehi, Aida.,Li, Zhi.,...&Suckling, John.(2020).Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia.TRANSLATIONAL PSYCHIATRY,10(1),14. |
| MLA | Rollins, Colleen P. E.,et al."Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia".TRANSLATIONAL PSYCHIATRY 10.1(2020):14. |
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来源：心理研究所
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