Resistance to apoptosis should not be taken as a hallmark of cancer
文献类型：期刊论文
| 作者 | Wang RuiAn1; Li ZengShan1; Yan QingGuo1; Bian XiuWu1; Ding YanQing1; Du Xiang2; Sun BaoCun1; Sun YunTian3; Zhang XiangHong1 |
| 刊名 | CHINESE JOURNAL OF CANCER
 |
| 出版日期 | 2014 |
| 卷号 | 33 |
| ISSN号 | 1000-467X |
| 关键词 | BREAST-CANCER PROGNOSTIC-SIGNIFICANCE BCL-2 EXPRESSION GROWTH TUMORIGENESIS REGULATORS MARKER CELLS Cancer apoptosis Bcl-2 hallmark |
| 其他题名 | Resistance to apoptosis should not be taken as a hallmark of cancer |
| 英文摘要 | In the research community, resistance to apoptosis is often considered a hallmark of cancer. However, pathologists who diagnose cancer via microscope often see the opposite. Indeed, increased apoptosis and mitosis are usually observed simultaneously in cancerous lesions. Studies have shown that increased apoptosis is associated with cancer aggressiveness and poor clinical outcome. Furthermore, overexpression of Bcl-2, an antiapoptotic protein, is linked with better survival of cancer patients. Conversely, Bax, CD95, Caspase-3, and other apoptosis-inducing proteins have been found to promote carcinogenesis. This notion of the role of apoptosis in cancer is not new; cancer cells were found to be short-lived 88 years ago. Given these observations, resistance to apoptosis should not be considered a hallmark of cancer. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5085880 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/46582]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 作者单位 | 1.中国科学院大连化学物理研究所 2.复旦大学 3.中国科学院合肥物质科学研究院肿瘤医院 |
| 推荐引用方式 GB/T 7714 | Wang RuiAn,Li ZengShan,Yan QingGuo,et al. Resistance to apoptosis should not be taken as a hallmark of cancer[J]. CHINESE JOURNAL OF CANCER,2014,33. |
| APA | Wang RuiAn.,Li ZengShan.,Yan QingGuo.,Bian XiuWu.,Ding YanQing.,...&Zhang XiangHong.(2014).Resistance to apoptosis should not be taken as a hallmark of cancer.CHINESE JOURNAL OF CANCER,33. |
| MLA | Wang RuiAn,et al."Resistance to apoptosis should not be taken as a hallmark of cancer".CHINESE JOURNAL OF CANCER 33(2014). |
入库方式： OAI收割
来源：合肥物质科学研究院
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