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Non-Invasive Biomarkers for Early Detection of Breast Cancer

文献类型：期刊论文

作者Li, Jiawei2; Guan, Xin2,3; Fan, Zhimin3; Ching, Lai-Ming1; Li, Yan2; Wang, Xiaojia4,5; Cao, Wen-Ming4,5; Liu, Dong-Xu2
刊名CANCERS
出版日期2020-10-01
卷号12
关键词breast cancer biomarker diagnosis detection blood body fluid
DOI10.3390/cancers12102767
通讯作者Cao, Wen-Ming(caowm@zjcc.org.cn) ; Liu, Dong-Xu(dong-xu.liu@aut.ac.nz)
英文摘要Simple Summary Early diagnosis of breast cancer greatly increases the chance of cure and survival from the disease. The mammogram is widely used for early detection of breast cancer, but its effectiveness and accuracy have been a concern for a long time as well as its inability in detecting small cancers, especially in women with dense breast tissues. Therefore, it is an unmet clinical need to develop a simple, convenient test to overcome the shortcomings of mammography. Liquid biopsy, which is based on the analysis of body fluids, has attracted much attention in the search for cancer biomarkers. Recent advances in analytical techniques have gradually made it possible to detect breast cancer early through a biomarker analysis of blood, nipple aspirate fluid, sweat, urine, tears, or the breath. We envision that a simple blood or breath test holds great promise as a biomarker for early detection of breast cancer in the near future. Breast cancer is the most common cancer in women worldwide. Accurate early diagnosis of breast cancer is critical in the management of the disease. Although mammogram screening has been widely used for breast cancer screening, high false-positive and false-negative rates and radiation from mammography have always been a concern. Over the last 20 years, the emergence of "omics" strategies has resulted in significant advances in the search for non-invasive biomarkers for breast cancer diagnosis at an early stage. Circulating carcinoma antigens, circulating tumor cells, circulating cell-free tumor nucleic acids (DNA or RNA), circulating microRNAs, and circulating extracellular vesicles in the peripheral blood, nipple aspirate fluid, sweat, urine, and tears, as well as volatile organic compounds in the breath, have emerged as potential non-invasive diagnostic biomarkers to supplement current clinical approaches to earlier detection of breast cancer. In this review, we summarize the current progress of research in these areas.
WOS关键词CIRCULATING TUMOR-CELLS ; NIPPLE ASPIRATE FLUID ; PROSTATE-SPECIFIC ANTIGEN ; EXTRACELLULAR VESICLES ; EXHALED BREATH ; ABERRANT METHYLATION ; VOLATILE BIOMARKERS ; MAMMARY-CARCINOMA ; MASS-SPECTROMETRY ; EARLY-DIAGNOSIS
资助项目key research-development program of Zhejiang Province[2020C04012] ; key research-development program of Zhejiang Province[2019C04001] ; Breast Cancer Foundation New Zealand ; New Zealand Breast Cancer Cure ; Auckland Medical Research Foundation[5117014]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000584242800001
出版者MDPI
资助机构key research-development program of Zhejiang Province ; Breast Cancer Foundation New Zealand ; New Zealand Breast Cancer Cure ; Auckland Medical Research Foundation
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/105076]  
专题中国科学院合肥物质科学研究院
通讯作者Cao, Wen-Ming; Liu, Dong-Xu
作者单位1.Univ Auckland, Fac Med & Hlth Sci, Auckland Canc Soc, Res Ctr, Auckland 1023, New Zealand
2.Auckland Univ Technol, Fac Hlth & Environm Sci, Sch Sci, Ctr Biomed & Chem Sci, Auckland 1010, New Zealand
3.Jilin Univ, First Hosp Jilin Univ, Dept Breast Surg, Changchun 130021, Peoples R China
4.Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Breast Med Oncol,Canc Hosp, Hangzhou 310022, Peoples R China
5.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310022, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jiawei,Guan, Xin,Fan, Zhimin,et al. Non-Invasive Biomarkers for Early Detection of Breast Cancer[J]. CANCERS,2020,12.
APA Li, Jiawei.,Guan, Xin.,Fan, Zhimin.,Ching, Lai-Ming.,Li, Yan.,...&Liu, Dong-Xu.(2020).Non-Invasive Biomarkers for Early Detection of Breast Cancer.CANCERS,12.
MLA Li, Jiawei,et al."Non-Invasive Biomarkers for Early Detection of Breast Cancer".CANCERS 12(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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