ZC3H12D is a prognostic biomarker associated with immune cell infiltration in lung adenocarcinoma
文献类型：期刊论文
| 作者 | Gong, Wangang1,2,3; Dai, Wumin1,2,3; Wei, Haibin1,2,3; Chen, Yongyi1,2,3; Zheng, Zhiguo1,2,3 |
| 刊名 | TRANSLATIONAL CANCER RESEARCH
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 9 |
| ISSN号 | 2218-676X |
| 关键词 | Bioinformatics analysis lung adenocarcinoma (LUAU) infiltration of immune cells ZC3H12D |
| DOI | 10.21037/tcr-20-1465 |
| 通讯作者 | Zheng, Zhiguo(zhengzg@zjcc.org.cn) |
| 英文摘要 | Background: ZC3H12 family members have an important role in tumorigenesis and development. However, the relationship between ZC3H12 family members and the prognosis of lung adenocarcinoma (LUAD) and tumor infiltrating lymphocytes is not clear. Methods: The expression of ZC3H12 family members in LUAD was analyzed by UALCAN. UALCAN, Kaplan-Meier Plotter, and GEPIA were used to evaluate the effect of ZC3H12 family members on the prognosis of LUAD. The relationship between prognostic ZC3H12 family members and 14 functional states of LUAD was studied by CancerSEA. The correlation between ZC3H12 and immune cell infiltration was studied by TIMMER. In addition, the correlation between ZC3H12D expression and an immune infiltration gene marker set was analyzed by TISIDB and GEPIA. Finally, the expression of ZC3H12D in LUAD was further verified by the GEO database and immunohistochemical staining. Results: The combined prognostic analysis of UALCAN, Kaplan-Meier Plotter, and GEPIA showed that the up-regulated expression of ZC3H12D mRNA was closely related to an improvement in overall survival rate (OS) in patients with LUAD. There was no significant correlation between ZC3H12D and 14 functional states of LUAD. Further analysis showed that the expression of ZC3H12D was positively correlated with the infiltration of B cells and CD4+T cells in LUAD. The expression of ZC3H12D was also positively correlated with immune markers in LUAD, including B cell-derived TNF and LTA cytokines, CXCL13, and its receptor CXCR5. Immunohistochemical staining showed that the expression of ZC3H12D in LUAD tissue samples was higher than normal lung tissues. Conclusions: These findings suggest that multiple ZC3H12 family members are associated with the prognosis of patients with LUAD tumors. The increased expression of ZC3H12D was correlated with improved prognosis. ZC3H12D was shown to be associated with the level of immune cell infiltration, including B cells and CD4+T cells. Thus, ZC3H12D can be used as a biomarker to judge the prognosis and immune infiltration of LUAD. |
| WOS关键词 | B-CELLS ; WEB SERVER ; CANCER ; EXPRESSION ; TRANSCRIPTS |
| 资助项目 | Natural Science Foundation of Zhejiang Province[LY19H160003] ; Medical Health Science and Technology Project of Zhejiang Provincial[2018KY294] ; Zhejiang Cancer Hospital Biospecimen Repository ; National Human Genetic Resource Sharing Service Platform[2005DKA21300] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | AME PUBL CO |
| WOS记录号 | WOS:000585306900029 |
| 资助机构 | Natural Science Foundation of Zhejiang Province ; Medical Health Science and Technology Project of Zhejiang Provincial ; Zhejiang Cancer Hospital Biospecimen Repository ; National Human Genetic Resource Sharing Service Platform |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/105079]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zheng, Zhiguo |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Res Inst, Canc Hosp, Hangzhou, Peoples R China 3.Zhejiang Canc Hosp, Zhejiang Canc Res Inst, 1 Banshan Rd, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, Wangang,Dai, Wumin,Wei, Haibin,et al. ZC3H12D is a prognostic biomarker associated with immune cell infiltration in lung adenocarcinoma[J]. TRANSLATIONAL CANCER RESEARCH,2020,9. |
| APA | Gong, Wangang,Dai, Wumin,Wei, Haibin,Chen, Yongyi,&Zheng, Zhiguo.(2020).ZC3H12D is a prognostic biomarker associated with immune cell infiltration in lung adenocarcinoma.TRANSLATIONAL CANCER RESEARCH,9. |
| MLA | Gong, Wangang,et al."ZC3H12D is a prognostic biomarker associated with immune cell infiltration in lung adenocarcinoma".TRANSLATIONAL CANCER RESEARCH 9(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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