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Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values

文献类型：期刊论文

作者Zhu, Weiwei1,2; Chen, Xiangsong1,2; Yuan, Lixia2; Wu, Jinyong2; Yao, Jianming2
刊名MOLECULES
出版日期2020-11-01
卷号25
关键词degradation kinetics pH dependence hydrogen peroxide shelf life N-acetylneuraminic acid
DOI10.3390/molecules25215141
通讯作者Yuan, Lixia(lxyuan@ipp.ac.cn) ; Yao, Jianming(jmyao@ipp.ac.cn)
英文摘要The objective of this study was to investigate the stability and degradation kinetics of N-acetylneuraminic acid (Neu5Ac). The pH of the solution strongly influenced the stability of Neu5Ac, which was more stable at neutral pH and low temperatures. Here, we provide detailed information on the degradation kinetics of Neu5Ac at different pH values (1.0, 2.0, 11.0 and 12.0) and temperatures (60, 70, 80 and 90 degrees C). The study of the degradation of Neu5Ac under strongly acidic conditions (pH 1.0-2.0) is highly pertinent for the hydrolysis of polysialic acid. The degradation kinetics of alkaline deacetylation were also studied. Neu5Ac was highly stable at pH 3.0-10.0, even at high temperature, but the addition of H2O2 greatly reduced its stability at pH 5.0, 7.0 and 9.0. Although Neu5Ac has a number of applications in products of everyday life, there are no reports of rigorous shelf-life studies. This research provides kinetic data that can be used to predict product shelf lives at different temperatures and pH values.
WOS关键词SIALIC-ACID ; THERMAL-DEGRADATION ; AQUEOUS-SOLUTION ; ANTHOCYANINS ; NMR ; SULFORAPHANE ; STABILITY
资助项目National Natural Science Foundation of China Youth Science Foundation Project[21506235]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000589213500001
出版者MDPI
资助机构National Natural Science Foundation of China Youth Science Foundation Project
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/105133]  
专题中国科学院合肥物质科学研究院
通讯作者Yuan, Lixia; Yao, Jianming
作者单位1.Univ Sci & Technol China, Hefei 230026, Peoples R China
2.Chinese Acad Sci, Inst Plasma Phys, Hefei Inst Phys Sci, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Weiwei,Chen, Xiangsong,Yuan, Lixia,et al. Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values[J]. MOLECULES,2020,25.
APA Zhu, Weiwei,Chen, Xiangsong,Yuan, Lixia,Wu, Jinyong,&Yao, Jianming.(2020).Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values.MOLECULES,25.
MLA Zhu, Weiwei,et al."Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values".MOLECULES 25(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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