WNT/beta-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma
文献类型：期刊论文
| 作者 | Zhu, Liang1,2,3 ; Yang, Shifeng1,2,3; Zheng, Linfeng1,2,3; Zhang, Gu1,2,3; Cheng, Guoping1,2,3
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| 刊名 | JOURNAL OF THORACIC DISEASE
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| 出版日期 | 2020-10-01 |
| 卷号 | 12 |
| 关键词 | Micropapillary-predominant adenocarcinoma (MPA) WNT/beta-catenin Axin1 lymph node invasion |
| ISSN号 | 2072-1439 |
| DOI | 10.21037/jtd-20-1495 |
| 通讯作者 | Cheng, Guoping(chenggp@zjcc.org.cn) |
| 英文摘要 | Background: Micropapillary-predominant adenocarcinoma (MPA) of the lung is associated with extensive lymph node involvement and rapid terminal metastasis. However, this subtype has been recognized for only a few years, and there have been few studies of the molecular mechanisms associated with its highly invasive behaviors. Methods: The present study utilized immunohistochemical staining of surgically resected tissue blocks of MPA and lepidic-predominant lung adenocarcinoma to quantify the expression of specific biological markers in the WNT/beta-catenin pathway and evaluate their influence on the lymph nodes invasion of these two types of lung adenocarcinomas. Results: Our findings revealed that disruption of the cell membrane cadherin-catenin complex, which weakens the tumor cell adherence of MPA, was caused by the dissociation of beta-catenin from the cadherin-catenin complex and the subsequent accumulation of beta-catenin in the cytoplasm. This caused abnormal activation of the WNT/beta-catenin pathway. We also found that Wnt-1-specific overexpression and Axin1 inhibition in MPA could explain the redistribution and cytoplasmic retention of beta-catenin. Collectively, these findings suggest that an abnormality in the WNT/beta-catenin pathway could enhance the invasiveness of MPA through the overexpression of Wnt-1 and downregulation of Axin1 molecules. Conclusions: Our data support the need for further research regarding the WNT/beta-catenin pathway and the need to develop novel targeted therapies for restoration of tumor cell adherence and improvement of the prognosis of MPA. |
| WOS关键词 | PROMOTES TUMOR PROGRESSION ; CANCER ; METASTASIS ; EXPRESSION ; MECHANISMS ; PLASTICITY ; RESISTANCE ; MUTATIONS ; STABILITY ; SUBTYPES |
| 资助项目 | National Natural Science Foundation of China[81702851] ; Zhejiang Province Medical and Health Science and Technology Project[2018KY030] ; Zhejiang Provincial Natural Science Foundation of China[LGF20H160008] |
| WOS研究方向 | Respiratory System |
| 语种 | 英语 |
| WOS记录号 | WOS:000583404900068 |
| 出版者 | AME PUBL CO |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Province Medical and Health Science and Technology Project ; Zhejiang Provincial Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/105154]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Cheng, Guoping |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Dept Pathol, Canc Hosp, Hangzhou 310022, Peoples R China 3.Zhejiang Canc Hosp, Dept Pathol, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Liang,Yang, Shifeng,Zheng, Linfeng,et al. WNT/beta-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma[J]. JOURNAL OF THORACIC DISEASE,2020,12. |
| APA | Zhu, Liang,Yang, Shifeng,Zheng, Linfeng,Zhang, Gu,&Cheng, Guoping.(2020).WNT/beta-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma.JOURNAL OF THORACIC DISEASE,12. |
| MLA | Zhu, Liang,et al."WNT/beta-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma".JOURNAL OF THORACIC DISEASE 12(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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