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Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study

文献类型：期刊论文

作者Shu, Zekai9,10,11; Zeng, Ziyi7,8; Yu, Bingqi6; Huang, Shuang10,11; Hua, Yonghong10,11; Jin, Ting10,11; Tao, Changjuan10,11; Wang, Lei10,11; Cao, Caineng10,11; Xu, Zumin5
刊名FRONTIERS IN ONCOLOGY
出版日期2020-11-06
卷号10
关键词radiation– induced oral mucositis radiotherapy nutritional status nasopharyngeal carcinoma (NPC) head and neck cancer
ISSN号2234-943X
DOI10.3389/fonc.2020.594687
通讯作者Lu, Lixia(lulx@sysucc.org.cn) ; Chen, Yuanyuan(chenyy@zjcc.org.cn)
英文摘要Background and Aims Malnutrition is a concern in patients with nasopharyngeal carcinoma (NPC) during chemoradiotherapy (CRT)/radiotherapy (RT), which is considered to be related with radiation-induced oral mucositis (ROM). The study aimed to evaluate the nutritional status of NPC patients during RT and investigate its association with ROM. Methods A prospective study was conducted in NPC patients. Patients were divided into three subgroups (mild, moderate, and severe groups) based on the duration of severe ROM (>= grade 3). Body weight, body mass index (BMI), albumin, prealbumin, NRS2002, and ROM grade were assessed on a weekly basis before and during CRT/RT. The statistical analysis was performed in the overall group and between three subgroups. Results A total of 176 patients were included. In the overall group, body weight and BMI kept decreasing since week 1 of RT, and NRS2002 score and ROM grade increased (p < 0.001). NRS2002 score and prealbumin levels were significantly different between each subgroup (p <= 0.046). Significant differences were observed in the proportion of patients receiving enteral nutrition, duration of parenteral nutrition, and total calories provided by nutritional support among three subgroups (p = 0.045-0.001). Conclusions Malnutrition occurred early in NPC patients and worsened continuously during RT. ROM was strongly associated with nutritional status. Nutritional support should be provided at the start of RT, especially in patients at high-risk of severe ROM.
WOS关键词WEIGHT-LOSS ; NECK-CANCER ; RISK-FACTORS ; HEAD ; PREDICTORS ; MANAGEMENT ; OUTCOMES ; INDEX ; INTERRUPTIONS ; MALNUTRITION
资助项目Qilu Pharmaceutical Co., Ltd.
WOS研究方向Oncology
语种英语
WOS记录号WOS:000590525800001
出版者FRONTIERS MEDIA SA
资助机构Qilu Pharmaceutical Co., Ltd.
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/105314]  
专题中国科学院合肥物质科学研究院
通讯作者Lu, Lixia; Chen, Yuanyuan
作者单位1.Nanjing Med Univ, Dept Radiat Oncol, Affiliated Huaian Peoples Hosp 1, Huaian, Peoples R China
2.CSNO, Chinese Soc Nutr Oncol, Tianjin, Peoples R China
3.Zhengzhou Univ, Affiliated Canc Hosp, Dept Radiat Oncol, Zhengzhou, Peoples R China
4.Hangzhou YITU Healthcare Technol Co Ltd, Hangzhou, Peoples R China
5.Guangdong Med Univ, Affiliated Hosp, Canc Ctr, Zhanjiang, Peoples R China
6.Zhejiang Hosp, Dept Oncol, Hangzhou, Peoples R China
7.Sun Yat Sen Univ, Canc Ctr, Dept Radiat Oncol, Guangzhou, Peoples R China
8.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China,Canc Ctr, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Guangzhou, Peoples R China
9.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China
10.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Shu, Zekai,Zeng, Ziyi,Yu, Bingqi,et al. Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study[J]. FRONTIERS IN ONCOLOGY,2020,10.
APA Shu, Zekai.,Zeng, Ziyi.,Yu, Bingqi.,Huang, Shuang.,Hua, Yonghong.,...&Chen, Yuanyuan.(2020).Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study.FRONTIERS IN ONCOLOGY,10.
MLA Shu, Zekai,et al."Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study".FRONTIERS IN ONCOLOGY 10(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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