Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Shikonin in Colon Cancer
文献类型：期刊论文
| 作者 | Chen, Yang1; Gao, Yun2,3,4; Yi, Xiaojiao1; Zhang, Jinghui1; Chen, Zhongjian2,3,4; Wu, Yongjiang1 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2020-10-22 |
| 卷号 | 11 |
| 关键词 | transcriptomics metabolomics shikonin colon cancer purine metabolism |
| ISSN号 | 1663-9812 |
| DOI | 10.3389/fphar.2020.544647 |
| 通讯作者 | Chen, Zhongjian(chenzj@zjcc.org.cn) ; Wu, Yongjiang(yjwu@zju.edu.cn) |
| 英文摘要 | Colorectal cancer is a common malignancy occurring in the digestive system, which is the third common cause of cancer mortality in developed countries. Shikonin, a naphthoquinone compound extracted from the root of Lithospermum erythrorhizon, is extensively reported to exert antitumor activity against various types of cancer. However, the systematic effect of shikonin in colon cancer remains poorly understood. In the present study, we evaluated the antitumor activity of shikonin in human colon cancer cells and the therapeutic effect on a xenograft mouse model. Transcriptomics and metabolomics were further integrated to provide a systematic perspective of the shikonin-induced antitumor mechanism. The results demonstrated that shikonin had a remarkable antitumor potency both in vitro and in vivo. Moreover, metabolic pathways, including the purine metabolism, amino acid metabolism, and glycerophospholipid metabolism, were perturbed and subsequently led to cell cycle arrest in the G2/M phase. In particular, the disturbance of purine metabolism may account for the major mechanism resulting from shikonin antitumor activity. |
| WOS关键词 | NUCLEOTIDE-METABOLISM ; CELL-LINE ; PURINE ; NECROPTOSIS ; APOPTOSIS ; ADENOSINE ; PAICS |
| 资助项目 | National Great New Drug Research and Development project[2018ZX09201010] ; National Natural Science Foundation of China[81302840] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000592411700001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Great New Drug Research and Development project ; National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/105323]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Zhongjian; Wu, Yongjiang |
| 作者单位 | 1.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Canc Hosp, Hangzhou, Peoples R China 4.Zhejiang Canc Hosp, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yang,Gao, Yun,Yi, Xiaojiao,et al. Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Shikonin in Colon Cancer[J]. FRONTIERS IN PHARMACOLOGY,2020,11. |
| APA | Chen, Yang,Gao, Yun,Yi, Xiaojiao,Zhang, Jinghui,Chen, Zhongjian,&Wu, Yongjiang.(2020).Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Shikonin in Colon Cancer.FRONTIERS IN PHARMACOLOGY,11. |
| MLA | Chen, Yang,et al."Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Shikonin in Colon Cancer".FRONTIERS IN PHARMACOLOGY 11(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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