Decline in serum progastrin-releasing peptide predicts the response of patients with small cell lung cancer to chemotherapy
文献类型：期刊论文
| 作者 | Li, Ming1,3,4; Han, Dandan1; Wang, Wei4 ; Zhang, Yang1; Li, Dan1; Dai, Chunyang1; Qian, Liting1; Lin, Wenchu2,4
|
| 刊名 | ONCOLOGY LETTERS
 |
| 出版日期 | 2020-12-01 |
| 卷号 | 20 |
| 关键词 | progastrin-releasing peptide therapeutic monitoring small-cell lung cancer neuron-specific enolase |
| ISSN号 | 1792-1074 |
| DOI | 10.3892/ol.2020.12164 |
| 通讯作者 | Lin, Wenchu(wenchu@hmfl.ac.cn) |
| 英文摘要 | The utility of serum progastrin-releasing peptide (ProGRP) and neuron-specific enolase (NSE) as biomarkers for treatment monitoring and as prognostic factors was investigated in small cell lung cancer (SCLC) patients. Patients were first diagnosed pathologically at the First Affiliated Hospital of the University of Science and Technology of China and had their serum ProGRP and NSE levels measured using an electrochemiluminescence immunoassay. A total of 120 SCLC patients were enrolled. In responsive patients, ProGRP levels decreased significantly following two cycles of chemotherapy and continued to decline over the course of treatment. However, this decrease in ProGRP levels was not observed in non-responsive patients. Changes in ProGRP levels were more accurate than changes in NSE levels for monitoring the effects of chemotherapy in patients with SCLC. Following two treatment cycles or after the occurrence of drug resistance, changes in ProGRP levels in patients with low ProGRP levels at the time of diagnosis were not notably, regardless of whether or not patients were responders. The area under the receiver operating characteristic curve of the decline in ProGRP levels as a therapeutic biomarker of SCLC was 0.9643, and the cut-off value was 55.02%. A decline in ProGRP levels maybe a good predictor of objective response to chemotherapy in patients with SCLC with higher ProGRP levels at diagnosis. This model is expected to replace or be combined with imaging to predict chemotherapeutic treatment effects in patients with SCLC. |
| WOS关键词 | NEURON-SPECIFIC ENOLASE ; PROGRP ; DIAGNOSIS ; BIOMARKER ; SURVIVAL ; THERAPY ; NSE |
| 资助项目 | Fundamental Research Funds for the Central University[WK9110000025] ; Natural Science Foundation of Anhui Province[2008085MH288] ; Science and Technology Major Project of Anhui Province[18030801140] ; National Natural Science Foundation of China[81672647] ; National Ministry of Industry and Information Technology Science and Technology[2018MND102041] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000595649300070 |
| 出版者 | SPANDIDOS PUBL LTD |
| 资助机构 | Fundamental Research Funds for the Central University ; Natural Science Foundation of Anhui Province ; Science and Technology Major Project of Anhui Province ; National Natural Science Foundation of China ; National Ministry of Industry and Information Technology Science and Technology |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/105418]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lin, Wenchu |
| 作者单位 | 1.Univ Sci & Technol China, Affiliated Hosp 1, Dept Lab Diagnost, Hefei 230031, Anhui, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China 3.Univ Sci & Technol China, Hefei 230036, Anhui, Peoples R China 4.Chinese Acad Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ming,Han, Dandan,Wang, Wei,et al. Decline in serum progastrin-releasing peptide predicts the response of patients with small cell lung cancer to chemotherapy[J]. ONCOLOGY LETTERS,2020,20. |
| APA | Li, Ming.,Han, Dandan.,Wang, Wei.,Zhang, Yang.,Li, Dan.,...&Lin, Wenchu.(2020).Decline in serum progastrin-releasing peptide predicts the response of patients with small cell lung cancer to chemotherapy.ONCOLOGY LETTERS,20. |
| MLA | Li, Ming,et al."Decline in serum progastrin-releasing peptide predicts the response of patients with small cell lung cancer to chemotherapy".ONCOLOGY LETTERS 20(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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