The Predictive Value of Pre-therapeutic Serum Gamma-glutamyl transferase in Efficacy and Adverse Reactions to Neoadjuvant Chemotherapy among Breast Cancer Patients
文献类型：期刊论文
| 作者 | Sun, Lu1,2,3; Yin, Wenjin2; Wu, Ziping2; Wang, Yaohui2; Lu, Jinsong2 |
| 刊名 | JOURNAL OF BREAST CANCER
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 23 |
| 关键词 | Breast cancer Gamma-glutamyltransferase Neoadjuvant therapy Chemotherapy Prognosis |
| ISSN号 | 1738-6756 |
| DOI | 10.4048/jbc.2020.23.e59 |
| 通讯作者 | Lu, Jinsong(lujjss@163.com) |
| 英文摘要 | Purpose: Gamma-glutamyl transferase (GGT) has been reported as being involved in tumor progression. Previous studies documented a potential relationship between serum GGT level and survival outcome in several types of human malignancies. However, the association between serum GGT levels and response to neoadjuvant chemotherapy (NAC) has not yet been reported. The present study aimed to evaluate the association between pre-therapeutic serum GGT level and the efficacy, long-term survival, and adverse reactions of NAC and to investigate its role in predicting NAC sensitivity in patients with breast cancer. Methods: A total of 129 patients were recruited and stratified into 2 groups according to serum GGT level (< 29 U/L and >= 29 U/L). The association between pre-therapeutic serum GGT levels and clinicopathological parameters was examined. The correlation between pre-therapeutic serum GGT levels and pathological complete response (pCR) was analyzed using univariate and multivariate logistic regression. Survival analyses of relapse-free survival (RFS) and disease-free survival (DFS) were performed. Pearson's chi(2) test and multivariate logistic regression model were used to analyze the correlation between pre-therapeutic serum GGT levels and adverse reactions. Results: Pre-therapeutic serum GGT levels were associated with pCR among breast cancer patients treated with NAC. Multivariate analysis showed that low-level GGT significantly increased pCR rate. Patients in the high-level GGT group had poorer survival than those in the low-level GGT group. Subgroup analysis demonstrated that serum GGT level was potentially related to RFS and DFS in the hormone receptor-positive group. Low levels of GGT are significantly associated with a higher incidence of neutropenia. Conclusion: Pre-therapeutic serum GGT level is an independent and novel biomarker for predicting the efficiency, prognosis, and adverse reactions to NAC in breast cancer patients. Patients with low pre-therapeutic serum GGT levels are more likely to have higher pCR rates, better RFS and DFS, and higher hematologic toxicity. |
| WOS关键词 | PROGNOSTIC-SIGNIFICANCE ; CISPLATIN ; TRANSPEPTIDASE ; CELLS ; RISK ; ASSOCIATION ; MARKER ; TUMOR |
| 资助项目 | Shanghai Municipal Commission of Health and Family Planning[201640006] ; Science and Technology Commission of Shanghai Municipality[14411950202] ; Science and Technology Commission of Shanghai Municipality[15JC1402700] ; Clinical Research Plan of Shanghai Hospital Development Center[16CR3065B] ; Clinical Research Plan of Shanghai Hospital Development Center[SHDC 12016231] ; Nurturing Fund of Renji Hospital[PYMDT-002] ; Shanghai Training and Support Program for Young Physician[2012-105] ; National Natural Science Foundation of China[81172505] ; National Natural Science Foundation of China[81302302] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000585082900005 |
| 出版者 | KOREAN BREAST CANCER SOC |
| 资助机构 | Shanghai Municipal Commission of Health and Family Planning ; Science and Technology Commission of Shanghai Municipality ; Clinical Research Plan of Shanghai Hospital Development Center ; Nurturing Fund of Renji Hospital ; Shanghai Training and Support Program for Young Physician ; National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/105445]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lu, Jinsong |
| 作者单位 | 1.Zhejiang Canc Hosp, Dept Gynecol Oncol, Hangzhou, Zhejiang, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Breast Surg, 160 Pujian Rd, Shanghai 200127, Peoples R China 3.Univ Chinese Acad Sci, Dept Gynecol Oncol, Canc Hosp, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Lu,Yin, Wenjin,Wu, Ziping,et al. The Predictive Value of Pre-therapeutic Serum Gamma-glutamyl transferase in Efficacy and Adverse Reactions to Neoadjuvant Chemotherapy among Breast Cancer Patients[J]. JOURNAL OF BREAST CANCER,2020,23. |
| APA | Sun, Lu,Yin, Wenjin,Wu, Ziping,Wang, Yaohui,&Lu, Jinsong.(2020).The Predictive Value of Pre-therapeutic Serum Gamma-glutamyl transferase in Efficacy and Adverse Reactions to Neoadjuvant Chemotherapy among Breast Cancer Patients.JOURNAL OF BREAST CANCER,23. |
| MLA | Sun, Lu,et al."The Predictive Value of Pre-therapeutic Serum Gamma-glutamyl transferase in Efficacy and Adverse Reactions to Neoadjuvant Chemotherapy among Breast Cancer Patients".JOURNAL OF BREAST CANCER 23(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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