Surface-modulated and thermoresponsive polyphosphoester nanoparticles for enhanced intracellular drug delivery.
文献类型：期刊论文
| 作者 | Li Yang4; Wang Feng1 ; Sun TianMeng1; Du JinZhi4; Yang XianZhu2; Wang Jun1
|
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 57 |
| 关键词 | POLYMERIC MICELLES MULTIDRUG-RESISTANCE BLOCK-COPOLYMERS PH CANCER DOXORUBICIN DESIGN SIRNA CORE thermoresponsive drug release polyphosphoester drug resistance |
| ISSN号 | 1674-7291 |
| 其他题名 | Surface-modulated and thermoresponsive polyphosphoester nanoparticles for enhanced intracellular drug delivery |
| 英文摘要 | The chemical structure of end groups influenced the phase transition temperature of thermoresponsive polymers. We demonstrated a strategy for the preparation of the pH/thermo-responsive polymeric nanoparticles via subtle modification of end groups of thermoresponsive polymer segments with a carboxyl group and revealed its potential application for enhanced intracellular drug delivery. By developing a polymeric nanoparticle composed of poly(aliphatic ester) as the inner core and thermoresponsive polyphosphoester as the outer shell, we showed that end groups of thermoresponsive polyphosphoester segments modified by carboxyl groups exhibited a pH/thermo-responsive behavior due to the hydrophilic to hydrophobic transitions of the end groups in response to the pH. Moreover, by encapsulating doxorubicin into the hydrophobic core of such pH/thermo-responsive polymer nanoparticles, their intracellular delivery and cytotoxicity to wild-type and drug-resistant tumor cells were significantly enhanced through the phase-transition-dependent drug release that was triggered by endosomal/lysosomal pH. This novel strategy and the multi-responsive polymer nanoparticles achieved by the subtle chain-terminal modification of thermoresponsive polymers provide a smart platform for biomedical applications. |
| 资助项目 | [Ministry of Science and Technology of China] ; [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5123448 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/105768]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 作者单位 | 1.中国科学技术大学 2.合肥学院 3.中国科学院合肥物质科学研究院 4.University Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Yang,Wang Feng,Sun TianMeng,et al. Surface-modulated and thermoresponsive polyphosphoester nanoparticles for enhanced intracellular drug delivery.[J]. SCIENCE CHINA-CHEMISTRY,2014,57. |
| APA | Li Yang,Wang Feng,Sun TianMeng,Du JinZhi,Yang XianZhu,&Wang Jun.(2014).Surface-modulated and thermoresponsive polyphosphoester nanoparticles for enhanced intracellular drug delivery..SCIENCE CHINA-CHEMISTRY,57. |
| MLA | Li Yang,et al."Surface-modulated and thermoresponsive polyphosphoester nanoparticles for enhanced intracellular drug delivery.".SCIENCE CHINA-CHEMISTRY 57(2014). |
入库方式： OAI收割
来源：合肥物质科学研究院
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