Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma
文献类型：期刊论文
| 作者 | Zhang Hao2; Zhang Shuilong2; Xu Huimian2 |
| 刊名 | CHINESE MEDICAL JOURNAL
 |
| 出版日期 | 2010 |
| 卷号 | 123 |
| 关键词 | MUTATIONS DIAGNOSIS GISTS gastrointestinal stromal tumor gastric adenocarcinoma c-kit platelet-derived growth factor receptor alpha mutation |
| ISSN号 | 0366-6999 |
| 其他题名 | Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma |
| 英文摘要 | M azur and Clark introduced the term "gastrointestinal stromal tumor" (GIST).1 These tumors are thought to originate from mesenchymal stem cells that differentiate toward the interstitial cells of Cajal.2 Activation of c-kit or platelet-derived growth factor receptor alpha (PDGFRA) gene mutation has been shown to be a major force in GIST pathogenesis leading to down-stream phosphorylation of substrate proteins and subsequently activation of networks of signal transduction pathways that regulate cell proliferation, survival, apoptosis, motility and other important cell functions. Immunohistochemically, a great majority of GISTs show strong, diffuse c-kit expression. The diagnosis of GIST! is currently based on morphologic features and immunohistochemical demonstration of c-kit (CD117). However, in some cases c-kit immunoreactivity is weak or undetectable. Here we report a case of a c-kit negative mesenchymal neoplasm in which molecular analysis was required to establish the correct diagnosis of GIST. The synchronous appearance of c-kit positive GIST and other malignancies have been reported previously.3-6 To the best of our knowledge, this is the first report of a c-kit negative GIST of the stomach coexisting with a gastric adenocarcinoma |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4088815 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/106501]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 作者单位 | 1.中国科学院合肥物质科学研究院肿瘤医院 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhang Hao,Zhang Shuilong,Xu Huimian. Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma[J]. CHINESE MEDICAL JOURNAL,2010,123. |
| APA | Zhang Hao,Zhang Shuilong,&Xu Huimian.(2010).Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma.CHINESE MEDICAL JOURNAL,123. |
| MLA | Zhang Hao,et al."Coexistence of a c-kit negative gastrointestinal stromal tumor and a gastric mucinous adenocarcinoma".CHINESE MEDICAL JOURNAL 123(2010). |
入库方式： OAI收割
来源：合肥物质科学研究院
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