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Reduced serum VGF levels are linked with suicide risk in Chinese Han patients with major depressive disorder

文献类型：期刊论文

作者Li, Xingxing; Ge, Huifei; Zhou, Dongsheng; Wu, Xiangping; Qi, Gangqiao; Chen, Zan; Yu, Chang; Zhang, Yuanyuan; Yu, Haihang; Wang, Chuang
刊名BMC PSYCHIATRY
出版日期2020
卷号20期号:1
关键词CEREBROSPINAL-FLUID NEUROPEPTIDE-Y ANTIDEPRESSANT OREXIN
DOI10.1186/s12888-020-02634-9
英文摘要BackgroundVGF (nonacronymic) is a neuropeptide that plays an important role in the pathogenesis of major depressive disorder (MDD). However, no studies have yet investigated VGF levels in patients with MDD who are at risk of suicide. The purpose of the present study was to determine whether serum VGF levels are related to suicide risk in patients with MMD.MethodsA total of 107 patients with MDD and 40 normal control participated in the present study. The risk of suicide was assessed using the Nurses Global Assessment of Suicide Risk (NGASR). On this basis, 60 patients were assigned to a high-risk group (NGASR >= 9) and 47 were assigned to a low-risk group (NGASR<9). The severity of depression was measured using the 17-item Hamilton Depression Rating Scale (HDRS). Levels of serum VGF were determined using a double antibody sandwich enzyme-linked immunosorbent assay.ResultsSerum VGF levels in the high-risk group (883.34139.67pg/mL) were significantly lower than in the low-risk group (1020.56131.76pg/mL) and in the control group (1107.00 +/- 155.38pg/mL) (F=31.90, p<0.001). In patients with MDD, suicide risk was significantly negatively correlated with VGF levels (r=-0.55, p=0.001).Conclusions p id=PaR Reduced serum VGF levels are related to risk of suicide in patients with MDD, so VGF may be a biomarker of suicide risk in MDD.
学科主题Psychiatry
源URL[http://ir.nimte.ac.cn/handle/174433/19640]  
专题2020专题
2020专题_期刊论文
作者单位Wang, C (corresponding author), Ningbo Univ, Sch Med, Dept Physiol & Pharmacol, 818 Fenghua Rd, Ningbo 315211, Zhejiang, Peoples R China.
推荐引用方式
GB/T 7714		 Li, Xingxing,Ge, Huifei,Zhou, Dongsheng,et al. Reduced serum VGF levels are linked with suicide risk in Chinese Han patients with major depressive disorder[J]. BMC PSYCHIATRY,2020,20(1).
APA Li, Xingxing.,Ge, Huifei.,Zhou, Dongsheng.,Wu, Xiangping.,Qi, Gangqiao.,...&Wang, Chuang.(2020).Reduced serum VGF levels are linked with suicide risk in Chinese Han patients with major depressive disorder.BMC PSYCHIATRY,20(1).
MLA Li, Xingxing,et al."Reduced serum VGF levels are linked with suicide risk in Chinese Han patients with major depressive disorder".BMC PSYCHIATRY 20.1(2020).

入库方式： OAI收割

来源：宁波材料技术与工程研究所

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