Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder
文献类型：期刊论文
| 作者 | Tian, Haihua; Li, Guangxue; Xu, Guoan; Liu, Jimeng; Wan, Xiaohan; Zhang, Jiao; Xie, Shuguang; Cheng, Jia; Gao, Shugui |
| 刊名 | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
 |
| 出版日期 | 2020 |
| 关键词 | LONG-TERM POTENTIATION ALZHEIMERS-DISEASE SERUM-LEVELS KAPPA-B NLRP3 INTERLEUKIN-18 MEMORY PATHWAY BRAIN CELLS |
| DOI | 10.1007/s00406-020-01128-9 |
| 英文摘要 | Little is known about the pathophysiology of memory deficits in patients with major depressive disorder (MDD) treated with modified electroconvulsive therapy (MECT). This study examined the profiles of cytokines, the memory function, and their association in MECT-treated MDD patients. Forty first-episode, drug-free MDD patients and 40 healthy controls were recruited. MECT was started with antidepressant treatment at a stable initial dose. The Wechsler Memory Scale (WMS) and Hamilton Rating Scale for Depression 17 (HRSD-17) were used to assess the cognitive function. MDD patients were divided into the memory impairment group (WMS < 50) and the non-memory impairment group (WMS >= 50) based on the total WMS scores after MECT. The levels of NOD-like receptor 3 (NLRP3) inflammasome, interleukin-18 (IL-18) and nuclear factor kappa-B (NF-kappa B) in the serum were measured. MDD patients showed significantly higher levels of NLRP3 inflammasome, IL-18 and NF-kappa B than that in the controls prior to MECT, and the levels also significantly increased after MECT. In MDD patients, the serum levels of these inflammatory cytokines were negatively associated with the total WMS scores and likely contributed to the scores independently. The receiver operating characteristic curve showed that the serum levels of these inflammatory cytokines may predict the cognitive impairment risk in MDD patients receiving MECT. Abnormal levels of NLRP3 inflammasome, IL-18 and NF-kappa B reflecting the disturbed balance of pro-inflammatory and anti-inflammatory mechanisms likely contribute to the MECT-induced cognitive deficits in MDD patients. |
| 学科主题 | Neurosciences & Neurology ; Psychiatry |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/19672]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Cheng, J (corresponding author), Xiamen Univ, Zhongshan Hosp, Xiamen 361004, Peoples R China. 2.Cheng, J 3.Gao, SG (corresponding author), Ningbo Kangning Hosp, Dept Affect Disorder, Ningbo 315201, Zhejiang, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Tian, Haihua,Li, Guangxue,Xu, Guoan,et al. Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2020. |
| APA | Tian, Haihua.,Li, Guangxue.,Xu, Guoan.,Liu, Jimeng.,Wan, Xiaohan.,...&Gao, Shugui.(2020).Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. |
| MLA | Tian, Haihua,et al."Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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