Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer
文献类型：期刊论文
| 作者 | Xing, Yan; Jiang, Zhenqi; Akakuru, Ozioma Udochukwu; He, Yan; Li, Aiguo; Li, Juan; Wu, Aiguo |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2020 |
| 卷号 | 189 |
| 关键词 | METAL-ORGANIC FRAMEWORKS ONE-POT SYNTHESIS ZIF-90 MEMBRANE FAVORABLE BIOCOMPATIBILITY DRUG-RESISTANCE DELIVERY NANOPARTICLES SELECTIVITY DOXORUBICIN ATP |
| DOI | 10.1016/j.colsurfb.2020.110837 |
| 英文摘要 | Epithelial ovarian cancer is still the leading cause of death in gynecology due to its resistance to platinum-based first-line chemotherapeutic drugs. The utilization of mitochondria-targeted drugs has become an important direction in anti-tumor drug research and development. In this work, cisplatin (DDP)-loaded ZIF-90 with mitochondrial-targeting was synthesized at room temperature with a high drug loading (11.7 %, calculated based on Pt content). The ZIF-90@DDP showed high cellular uptake and less toxicity in both non- and DDP-resistant ovarian cancer cells with effective pH- and ATP-responsive drug release. Both mitochondria-targeting and responsive drug release could increase the drug concentration in mitochondria of drug-resistant cancer cells to reverse such resistance. Conclusively, the mitochondria-targeting ZIF-90@DDP with high drug loading could trigger responsive drug release in mitochondria of epithelial ovarian cancer cells, inhibit DPP-resistant epithelial ovarian cancer cells, and reverse drug resistance. |
| 学科主题 | Biophysics ; Chemistry ; Materials Science |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/19716]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Li, J 2.Wu, AG (corresponding author), Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices,Cixi Inst Biomed, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Xing, Yan,Jiang, Zhenqi,Akakuru, Ozioma Udochukwu,et al. Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2020,189. |
| APA | Xing, Yan.,Jiang, Zhenqi.,Akakuru, Ozioma Udochukwu.,He, Yan.,Li, Aiguo.,...&Wu, Aiguo.(2020).Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer.COLLOIDS AND SURFACES B-BIOINTERFACES,189. |
| MLA | Xing, Yan,et al."Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer".COLLOIDS AND SURFACES B-BIOINTERFACES 189(2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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