Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields
文献类型：期刊论文
| 作者 | Wu, Tingting; Zhang, Qian; Hu, Huiping; Yang, Fang; Li, Ke; Zhang, Yu; Shi, Chen |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2020 |
| 卷号 | 10期号:25页码:14471-14481 |
| 关键词 | NANOPARTICLES TETRANDRINE INHIBITION RESISTANCE APOPTOSIS PATHWAYS RELEASE IRON |
| DOI | 10.1039/d0ra01458c |
| 英文摘要 | Magnetic nanoparticles have been widely used in cancer treatment for their potential magnetic functions and synergistic antitumor effect with therapeutic agents. In this work, we developed a polymeric nanosystem by co-loading the natural anticancer drug tetrandrine and superparamagnetic iron oxide nanoparticles for cancer combinatorial therapy. The nanosystem possessed regular morphology and superior magnetic properties. Under the action of external rotating permanent magnets, the nanosystem could transfer a rotational motion to damage the cellular membrane, which would result in the increased permeabilization of the cell membrane and damage to lysosomes. Hence, the specific characteristics of the magnetic nanosystem induced potent cytotoxicity and enhanced the effect of the tetrandrine-induced cell apoptosis. With further exploration, we found that this nanoplatform caused cell death via a lysosomal-mitochondrial apoptotic pathway with the upregulation of proapoptotic proteins (Cathepsin B, Smac/Diablo, Cytochrome C, and Caspase 3) and the down-regulation of antiapoptotic proteins (Bcl-2 and XIAP). These findings demonstrate that the combination therapy mediated by co-loaded magnetic nanosystems can be used for a multi-therapeutic effect against tumors in biomedical applications. |
| 学科主题 | Chemistry |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/19788]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Shi, C (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan, Peoples R China. 2.Shi, C (corresponding author), Hubei Prov Clin Res Ctr Precis Med Crit Illness, Wuhan 430022, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Wu, Tingting,Zhang, Qian,Hu, Huiping,et al. Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields[J]. RSC ADVANCES,2020,10(25):14471-14481. |
| APA | Wu, Tingting.,Zhang, Qian.,Hu, Huiping.,Yang, Fang.,Li, Ke.,...&Shi, Chen.(2020).Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields.RSC ADVANCES,10(25),14471-14481. |
| MLA | Wu, Tingting,et al."Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields".RSC ADVANCES 10.25(2020):14471-14481. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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