Amplified Photoacoustic Signal and Enhanced Photothermal Conversion of Polydopamine-Coated Gold Nanobipyramids for Phototheranostics and Synergistic Chemotherapy
文献类型：期刊论文
| 作者 | Liu, Yanhong; Li, Ziwei; Yin, Zhibin; Zhang, Hongxin; Gao, Yang; Huo, Guoyan; Wu, Aiguo; Zeng, Leyong |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2020 |
| 卷号 | 12期号:13页码:14866-14875 |
| 关键词 | PHOTODYNAMIC THERAPY NANOPARTICLES CHEMO NANOPLATFORM PLATFORM OXIDE |
| DOI | 10.1021/acsami.9b22979 |
| 英文摘要 | Light-responsive nanoprobes were suffering from the threat of high-dose laser irradiation, and it was important for constructing new nanoprobes for safe and efficient photo-theranostics. Here, polydopamine (PDA)-coated gold nano-bipyramids (AuNBPs@PDA) were synthesized for amplified photoacoustic (PA) signal and enhanced photothermal conversion with low-dose laser irradiation and then doxorubicin (DOX)-loaded AuNBPs@PDA-DOX nanoprobes were constructed for PA imaging-guided synergistic photothermal therapy (PTT) and chemotherapy. The AuNBPs@PDA nanoparticles possessed higher photothermal conversion efficiency (42.07%) and stronger PA signal than those of AuNBP nanoparticles, and the AuNBPsg PDA-DOX nanoprobes showed dual-responsive DOX release of pH and photothermal stimulation. With low-dose laser irradiation (1.0 W/cm(2)) and low-concentration AuNBPs@PDA-DOX (60 mu g/mL), the 4T1 cell viability was reduced to about 5%, owing to the combination of PTT and chemotherapy, compared with 42.3% of single chemotherapy and 25.3% of single PTT. Moreover, by modeling 4T1 tumor-bearing nude mice, in vivo PA imaging was achieved and the tumors were completely inhibited, demonstrating the excellent synergistic effect of PTT/chemotherapy. Therefore, the developed AuNBPs@PDA-DOX nanoprobes can be used for phototheranostics and synergistic chemotherapy, achieving low-dose laser irradiation and high-efficient visualized theranostics. |
| 学科主题 | Science & Technology - Other Topics ; Materials Science |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/19821]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Zeng, LY (corresponding author), Hebei Univ, Coll Chem & Environm Sci, Key Lab Med Chem & Mol Diag, Chem Biol Key Lab Hebei Prov,Minist Educ, Baoding 071002, Peoples R China. 2.Huo, GY 3.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices,Key Lab Addit Mf, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Liu, Yanhong,Li, Ziwei,Yin, Zhibin,et al. Amplified Photoacoustic Signal and Enhanced Photothermal Conversion of Polydopamine-Coated Gold Nanobipyramids for Phototheranostics and Synergistic Chemotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(13):14866-14875. |
| APA | Liu, Yanhong.,Li, Ziwei.,Yin, Zhibin.,Zhang, Hongxin.,Gao, Yang.,...&Zeng, Leyong.(2020).Amplified Photoacoustic Signal and Enhanced Photothermal Conversion of Polydopamine-Coated Gold Nanobipyramids for Phototheranostics and Synergistic Chemotherapy.ACS APPLIED MATERIALS & INTERFACES,12(13),14866-14875. |
| MLA | Liu, Yanhong,et al."Amplified Photoacoustic Signal and Enhanced Photothermal Conversion of Polydopamine-Coated Gold Nanobipyramids for Phototheranostics and Synergistic Chemotherapy".ACS APPLIED MATERIALS & INTERFACES 12.13(2020):14866-14875. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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