Self-assembled, biocompatible and biodegradable TEMPO-conjugated nanoparticles enable folate-targeted tumor magnetic resonance imaging
文献类型：期刊论文
| 作者 | Akakuru, Ozioma Udochukwu; Iqbal, M. Zubair; Liu, Chuang; Xing, Jie; Wei, Zhenni; Jiang, Zhenqi; Fang, Qianlan; Yuan, Bo; Nosike, Elvis Ikechukwu; Xia, Jianbi |
| 刊名 | APPLIED MATERIALS TODAY
 |
| 出版日期 | 2020 |
| 卷号 | 18 |
| 关键词 | IRON-OXIDE NANOPARTICLES RADICAL CONTRAST AGENTS IN-VITRO CHITOSAN PEG THERAPY SHELL |
| DOI | 10.1016/j.apmt.2019.100524 |
| 英文摘要 | Magnetic resonance imaging (MRI) signal intensities in tissues are usually enhanced by the injection of metal-based contrast agents (CAs) in patients. Some of these metal compounds have been linked to incurable nephrogenic systemic fibrosis and other neurological disorders, leading to their discontinuation. Herein, we report the design, synthesis, and characterization of a self-assembled metal-free CA which is based on an organic nitroxide radical (4-carboxy-TEMPO) compartmentalized in the biocompatible, biodegradable natural polymer, chitosan (CS), alongside folate targeting for in vivo tumor MRI. This extension conceivably heralds a new application for CS-TEMPO, which hitherto was used in macro-sizes as initiators for grafting CS to various polymers. Significantly, the folic acid (FA)-modified metal-free CA (CS-TEMPO-FA; average size similar to 113 nm) is substantially benign, with no evidence of acute toxicity; it exhibits desirable pharmacokinetic profile, enhanced stability in highly reducing environments, high nitroxide loading (molecular relaxivity similar to 18.56 mM(-1) s(-1)), and effective tumor targeting. This latter characteristic ameliorates the non-specific uptake of CAs by normal cells. CS-TEMPO-FA nanoparticles demonstrate commensurate contrast enhancement of the tumor region up to 1 h post-injection when injected into 4T1 tumor-bearing mice, a contrast enhancement capability hitherto unattained by TEMPO-based CAs. This work points to CS-TEMPO-FA as a potential alternative to metal-based CAs as well as an active folate-targeted metal-free CA for long-term longitudinal tumor MRI which ameliorates the otherwise short in vivo lifetimes of typical organic radicals-based CAs. (C) 2019 Elsevier Ltd. All rights reserved. |
| 学科主题 | Materials Science |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/19899]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Zheng, JJ (corresponding author), Univ Chinese Acad Sci, HwaMei Hosp, Dept Expt Med Sci, Ningbo, Zhejiang, Peoples R China. 2.Wu, AG (corresponding author), Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China. 3.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Zhejiang, Peoples R China. 4.Iqbal, MZ |
| 推荐引用方式 GB/T 7714 | Akakuru, Ozioma Udochukwu,Iqbal, M. Zubair,Liu, Chuang,et al. Self-assembled, biocompatible and biodegradable TEMPO-conjugated nanoparticles enable folate-targeted tumor magnetic resonance imaging[J]. APPLIED MATERIALS TODAY,2020,18. |
| APA | Akakuru, Ozioma Udochukwu.,Iqbal, M. Zubair.,Liu, Chuang.,Xing, Jie.,Wei, Zhenni.,...&Wu, Aiguo.(2020).Self-assembled, biocompatible and biodegradable TEMPO-conjugated nanoparticles enable folate-targeted tumor magnetic resonance imaging.APPLIED MATERIALS TODAY,18. |
| MLA | Akakuru, Ozioma Udochukwu,et al."Self-assembled, biocompatible and biodegradable TEMPO-conjugated nanoparticles enable folate-targeted tumor magnetic resonance imaging".APPLIED MATERIALS TODAY 18(2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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