Heparin reduced dialysis through a facile anti-coagulant coating on flat and hollow fiber membranes
文献类型：期刊论文
| 作者 | Liu, Yang; Han, Qiu; Li, Tiantain; Hua, Jing; Liu, Fu; Li, Qiang; Deng, Gang |
| 刊名 | JOURNAL OF MEMBRANE SCIENCE
 |
| 出版日期 | 2020 |
| 卷号 | 595 |
| 关键词 | POLYETHERSULFONE MEMBRANES ANTIFOULING PROPERTIES SURFACE MODIFICATION BLOOD COMPATIBILITY ANTICOAGULANT POLYMER HEMOCOMPATIBILITY PERFORMANCE MECHANISM CHITOSAN |
| DOI | 10.1016/j.memsci.2019.117593 |
| 英文摘要 | Heparin free prescription is highly desired for haemodialysis. Versatile strategies have been developed to address the anti-coagulation modification of dialysis membranes. We here develop a facile and effective method to construct an anticoagulant coating on polymeric membranes or a dialyzer through hydrophobic-hydrophobic interaction. An amphiphilic heparin-like copolymer was first synthesized via a free radical polymerization based on alkyl chain lauryl methacrylate (LMA), acrylic acid (AA), and sodium 4-vinylbenze-sulfonate (SSNa) segments. The specific structure of terpolymer was characterized via Fourier transform infrared spectra (FTIR), Proton nuclear magnetic resonance (H-1 NMR) spectra and size exclusion chromatography (SEC). The amphiphilic copolymer was anchored onto Polylactide (PLA) membrane surface from an aqueous-based solution via hydrophobic-hydrophobic interaction. An Attenuated total reflectance Fourier transform infrared spectra (ATR-FTIR), energy dispersive spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS) confirmed the successful immobilization of heparin-mimicking terpolymers. The modified membranes showed excellent antifouling property and hydrophilicity. Moreover, the membranes exhibited outstanding haemocompatibility with suppressed platelet adhesion, low complement activation (C3a and C5a), expanded coagulation time and limited haemolysis ratio. The prolonged activated partial thromboplastin time and thrombin time (APTT>600 s, TT > 140 s) certified the excellent self-anticoagulant performances. To further examine the applicability and effectiveness, a polysulfone dialyzer was modified by this strategy. The ultrafiltration coefficient and clearance performances were examined. Overall, the hydrophobic-hydrophobic interaction strategy simplified the modification procedure of dialysis membrane, implying its great potential in heparin free dialysis application. |
| 学科主题 | Engineering ; Polymer Science |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20097]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Hua, J (corresponding author), Qingdao Univ Sci & Technol, Shandong Prov Key Lab Rubber Plast, Minist Educ, Key Lab Rubber Plast, Qingdao 266042, Shandong, Peoples R China. 2.Liu, F (corresponding author), Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Liu, Yang,Han, Qiu,Li, Tiantain,et al. Heparin reduced dialysis through a facile anti-coagulant coating on flat and hollow fiber membranes[J]. JOURNAL OF MEMBRANE SCIENCE,2020,595. |
| APA | Liu, Yang.,Han, Qiu.,Li, Tiantain.,Hua, Jing.,Liu, Fu.,...&Deng, Gang.(2020).Heparin reduced dialysis through a facile anti-coagulant coating on flat and hollow fiber membranes.JOURNAL OF MEMBRANE SCIENCE,595. |
| MLA | Liu, Yang,et al."Heparin reduced dialysis through a facile anti-coagulant coating on flat and hollow fiber membranes".JOURNAL OF MEMBRANE SCIENCE 595(2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。