Ce6/Mn2+-chelated polydopamine@black-TiO2 nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer
文献类型：期刊论文
| 作者 | Gao, Yang; Zhang, Luyun; Liu, Yanhong; Sun, Sijia; Yin, Zhibin; Zhang, Lili; Li, Aiguo; Lu, Guangming; Wu, Aiguo; Zeng, Leyong |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2020 |
| 卷号 | 12期号:3页码:1801-1810 |
| 关键词 | HYDROGENATED BLACK TIO2 PHOTODYNAMIC THERAPY TITANIA NANOCOMPOSITES NANOPARTICLES NANOPLATFORM NANOSPHERES PLATFORM |
| DOI | 10.1039/c9nr09236f |
| 英文摘要 | Black titanium dioxide (TiO2) nanoparticles have attracted great attention due to their application in photothermal therapy (PTT). However, single-mode phototherapy has the risk of recurrence, and the high-dose laser usually imposed to improve the PTT performance can bring a potential threat to security. Here, polydopamine (PDA)-coated black TiO2 (b-P25@PDA) nanoparticles with a core-shell structure were synthesized for enhanced PTT; then, synergistic phototherapy nanoprobes (b-P25@PDA-Ce6 (Mn)) were constructed by coupling chlorin e6 (Ce6) and chelating Mn2+ for simultaneous photodynamic therapy (PDT)/PTT and magnetic resonance (MR) imaging, in which a low-dose laser was used and imaging-guided phototherapy with high efficiency and high safety was achieved. The prepared nanoprobes showed high photothermal conversion efficiency (32.12%), high reactive oxygen generation and excellent MR imaging. In the 4T1 tumor-bearing nude mouse model, the tumors completely disappeared under the combination of PDT/PTT with a low-dose laser but were only partially inhibited by single PDT and single PTT. The current work developed a multifunctional black TiO2-based nanoprobe for enhanced synergistic PDT/PTT and MR imaging, which will be important for the safe and efficient visualized theranostics of cancers. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20146]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Zeng, LY (corresponding author), Hebei Univ, Key Lab Med Chem & Mol Diag, Chem Biol Key Lab Hebei Prov, Coll Chem & Environm Sci,Minist Educ, Baoding 071002, Peoples R China. 2.Lu, GM (corresponding author), Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, Nanjing 210002, Peoples R China. 3.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Peoples R China. 4.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Gao, Yang,Zhang, Luyun,Liu, Yanhong,et al. Ce6/Mn2+-chelated polydopamine@black-TiO2 nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer[J]. NANOSCALE,2020,12(3):1801-1810. |
| APA | Gao, Yang.,Zhang, Luyun.,Liu, Yanhong.,Sun, Sijia.,Yin, Zhibin.,...&Zeng, Leyong.(2020).Ce6/Mn2+-chelated polydopamine@black-TiO2 nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer.NANOSCALE,12(3),1801-1810. |
| MLA | Gao, Yang,et al."Ce6/Mn2+-chelated polydopamine@black-TiO2 nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer".NANOSCALE 12.3(2020):1801-1810. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。