PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia
文献类型：期刊论文
| 作者 | Zhang, Tao; Jiang, Zhenqi; Chen, Libin; Pan, Chunshu; Sun, Shan; Liu, Chuang; Li, Zihou; Ren, Wenzhi; Wu, Aiguo; Huang, Pintong |
| 刊名 | NANO RESEARCH
 |
| 出版日期 | 2020 |
| 卷号 | 13期号:1页码:273-281 |
| 关键词 | OUTCOMES RELEASE |
| DOI | 10.1007/s12274-019-2610-6 |
| 英文摘要 | As nanomedicine-based clinical strategies have continued to develop, the possibility of combining chemotherapy and singlet oxygen-dependent photodynamic therapy (PDT) to treat pancreatic cancer (PaC) has emerged as a viable therapeutic modality. The efficacy of such an approach, however, is likely to be constrained by the mechanisms of drug release and tumor oxygen levels. In the present study, we developed an Fe(III)-complexed porous coordination network (PCN) which we then used to encapsulate PTX (PCN-Fe(III)-PTX) nanoparticles (NPs) in order to treat PaC via a combination of chemotherapy and PDT. The resultant NPs were able to release drug in response to both laser irradiation and pH changes to promote drug accumulation within tumors. Furthermore, through a Fe(III)-based Fenton-like reaction these NPs were able to convert H2O2 in the tumor site to O-2, thereby regulating local hypoxic conditions and enhancing the efficacy of PDT approaches. Also these NPs were suitable for use as a T-1-MRI weighted contrast agent, making them viable for monitoring therapeutic efficacy upon treatment. Our results in both cell line and animal models of PaC suggest that these NPs represent an ideal agent for mediating effective MRI-guided chemotherapy-PDT, giving them great promise for the clinical treatment of PaC. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20244]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Ren, WZ (corresponding author), Key Lab Diag & Treatment Digest Syst Tumors Zheji, Ningbo 315016, Zhejiang, Peoples R China. 2.Ren, WZ 3.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Zhejiang, Peoples R China. 4.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Zhejiang, Peoples R China. 5.Huang, PT (corresponding author), Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Ultrasound, Hangzhou 310009, Zhejiang, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zhang, Tao,Jiang, Zhenqi,Chen, Libin,et al. PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia[J]. NANO RESEARCH,2020,13(1):273-281. |
| APA | Zhang, Tao.,Jiang, Zhenqi.,Chen, Libin.,Pan, Chunshu.,Sun, Shan.,...&Huang, Pintong.(2020).PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia.NANO RESEARCH,13(1),273-281. |
| MLA | Zhang, Tao,et al."PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia".NANO RESEARCH 13.1(2020):273-281. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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