Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer
文献类型：期刊论文
| 作者 | Li, Ziwei; Yang, Fan; Wu, Di; Liu, Yanhong; Gao, Yang; Lian, Haichen; Zhang, Hongxin; Yin, Zhibin; Wu, Aiguo; Zeng, Leyong |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2020 |
| 卷号 | 12期号:43页码:22173-22184 |
| 关键词 | PHOTOTHERMAL THERAPY NANOPLATFORM CHEMOTHERAPY NANOPARTICLES COMBINATION DOXORUBICIN |
| DOI | 10.1039/d0nr05386d |
| 英文摘要 | Metastasis is the main cause of treatment failure in breast cancer, and integrated phototheranostics is a promising strategy to achieve both precision theranostics and metastasis inhibition. In this work, a multifunctional phototheranostic nanoprobe composed of chlorin e6 (Ce6)-conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) was synthesized for simultaneous photoacoustic (PA) imaging, photothermal therapy (PTT) and photodynamic therapy (PDT). Under the irradiation of near infrared laser, AuNSs@PDA showed enhanced photothermal conversion and amplified PA imaging performance, compared with single AuNSs. By the covalent conjugation of Ce6, the AuNSs@PDA-Ce6 nanoprobe showed robust stability and excellent singlet oxygen (O-1(2)) generation ability. Under the combination of PTT/PDT, the AuNSs@PDA-Ce6 nanoprobes significantly reduced the growth of 4T1 tumors and suppressed their lung metastasis. All the results demonstrated the considerable potential of AuNSs@PDA-Ce6 phototheranostic nanoprobes for precision theranostics and metastasis inhibition of breast cancer. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20333]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, Ningbo 315201, Peoples R China. 2.Zeng, LY (corresponding author), Hebei Univ, Inst Life Sci & Green Dev, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov,Minist Educ,Key Lab, Baoding 071002, Peoples R China. 3.Wu, D |
| 推荐引用方式 GB/T 7714 | Li, Ziwei,Yang, Fan,Wu, Di,et al. Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer[J]. NANOSCALE,2020,12(43):22173-22184. |
| APA | Li, Ziwei.,Yang, Fan.,Wu, Di.,Liu, Yanhong.,Gao, Yang.,...&Zeng, Leyong.(2020).Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer.NANOSCALE,12(43),22173-22184. |
| MLA | Li, Ziwei,et al."Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer".NANOSCALE 12.43(2020):22173-22184. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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