Rational design of nanomedicine for photothermal-chemodynamic bimodal cancer therapy
文献类型：期刊论文
| 作者 | Yao, Junlie; Zheng, Fang; Yao, Chenyang; Xu, Xiawei; Akakuru, Ozioma Udochukwu; Chen, Tianxiang; Yang, Fang; Wu, Aiguo |
| 刊名 | WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
 |
| 出版日期 | 2020 |
| 关键词 | PHOTODYNAMIC THERAPY TUMOR NANOPARTICLES NANOPLATFORM NANOMATERIALS COMBINATION IMPACT AGENT H2O2 |
| DOI | 10.1002/wnan.1682 |
| 英文摘要 | Given the diversity, complexity, and heterogeneity of persistent tumors, traditional nanoscale monotherapeutic systems suffer from dissatisfactory curative efficiency with incidence of metastasis or relapse. In parallel, the trend of clinical research on the basis of nanomedicines has increasingly shifted from monotherapy toward combinatorial therapy for admirable synergetic performances. In this regard, cutting-edge nanomedicines harnessing photothermal-chemodynamic bimodal therapy (PTT/CDT) have opened up a highly-efficient and relatively-safe cancer theranostic paradigm. Still, the integration of PTT/CDT functional units into one nanomedicine remains a herculean but meaningful task to achieve notable super-additive effects. This review aims to elucidate underlying synergistic interactions of PTT/CDT and highlight intriguing designs of nanomedicines for PTT/CDT including nanomaterial selection, performance optimization, multimodal therapy, visualization strategies, and targeting strategies. Furthermore, an outlook on further improvements of PTT/CDT is provided, emphasizing significant scientific issues that require remediation for clinical translation. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease |
| 学科主题 | Science & Technology - Other Topics ; Research & Experimental Medicine |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20352]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Yang, F 2.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. 3.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Yao, Junlie,Zheng, Fang,Yao, Chenyang,et al. Rational design of nanomedicine for photothermal-chemodynamic bimodal cancer therapy[J]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,2020. |
| APA | Yao, Junlie.,Zheng, Fang.,Yao, Chenyang.,Xu, Xiawei.,Akakuru, Ozioma Udochukwu.,...&Wu, Aiguo.(2020).Rational design of nanomedicine for photothermal-chemodynamic bimodal cancer therapy.WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY. |
| MLA | Yao, Junlie,et al."Rational design of nanomedicine for photothermal-chemodynamic bimodal cancer therapy".WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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