Boron-Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides
文献类型：期刊论文
| 作者 | Bregadze, Vladimir I.; Sivaev, Igor B.; Dubey, Ravindra Dhar; Semioshkin, Andrey; Shmal'ko, Akim V.; Kosenko, Irina D.; Lebedeva, Kseniya V.; Mandal, Swadhin; Sreejyothi, Prasannakumar; Sarkar, Arindam |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2020 |
| 卷号 | 26期号:61页码:13832-13841 |
| 关键词 | NEUTRON-CAPTURE THERAPY CLOSO-DODECABORATE ANION TARGETED LIPOSOMES OXONIUM DERIVATIVES CLUSTER LIPIDS DELIVERY AGENTS MURINE TUMORS ORAL-CANCER CHEMISTRY BIS(DICARBOLLIDES) |
| DOI | 10.1002/chem.201905083 |
| 英文摘要 | A series of boron-containing lipids were prepared by reactions of cyclic oxonium derivatives of polyhedron boranes and metallacarboranes (closo-dodecaborate anion, cobalt and iron bis(dicarbollides)) with amine and carboxylic acids which are derived from cholesterol. Stable liposomal formulations, on the basis of synthesized boron-containing lipids, hydrogenated soybeanl-alpha-phosphatidylcholine and (HSPC) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG) as excipients, were prepared and then characterized by dynamic light scattering (DLS) that revealed the formation of particles to be smaller than 200 nm in diameter. The resulting liposomal formulations showed moderate to excellent loading and entrapment efficiency, thus justifying the design of the compounds to fit in the lipid bilayer and ensuring ease of in vivo use for future application. The liposomal formulations based on cobalt and iron bis(dicarbollide)-based lipids were found to be nontoxic against both human breast normal epithelial cells MCF-10A and human breast cancer cells MCF-7. |
| 学科主题 | Chemistry |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20439]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Sarkar, A (corresponding author), India Innovat Res Ctr, 465 Patparganj Ind Area, Delhi 110092, India. 2.Shen, ZY (corresponding author), Southern Med Univ, Guangdong Prov Key Lab Construct & Detect Tissue, Biomat Res Ctr, Sch Biomed Engn, Guangzhou 510515, Peoples R China. 3.Bregadze, VI (corresponding author), Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28 Vavilov Str, Moscow 119991, Russia. |
| 推荐引用方式 GB/T 7714 | Bregadze, Vladimir I.,Sivaev, Igor B.,Dubey, Ravindra Dhar,et al. Boron-Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides[J]. CHEMISTRY-A EUROPEAN JOURNAL,2020,26(61):13832-13841. |
| APA | Bregadze, Vladimir I..,Sivaev, Igor B..,Dubey, Ravindra Dhar.,Semioshkin, Andrey.,Shmal'ko, Akim V..,...&Hosmane, Narayan S..(2020).Boron-Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides.CHEMISTRY-A EUROPEAN JOURNAL,26(61),13832-13841. |
| MLA | Bregadze, Vladimir I.,et al."Boron-Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides".CHEMISTRY-A EUROPEAN JOURNAL 26.61(2020):13832-13841. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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