Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy
文献类型：期刊论文
| 作者 | Jiang, Zhenqi; Yuan, Bo; Wang, Yinjie; Wei, Zhenni; Sun, Shan; Akakuru, Ozioma Udochukwu; Li, Yong; Li, Juan; Wu, Aiguo |
| 刊名 | NANO TODAY
 |
| 出版日期 | 2020 |
| 卷号 | 34 |
| 关键词 | METAL-ORGANIC FRAMEWORKS DRUG-DELIVERY FAVORABLE BIOCOMPATIBILITY PHOTODYNAMIC THERAPY CANCER NANOPARTICLES ATP |
| DOI | 10.1016/j.nantod.2020.100910 |
| 英文摘要 | Effective photothermal therapy (PTT) under low temperature (< 50 degrees C) and power density (< 0.4 W/cm(2)) avoiding the damage of skin and normal organs. Here, we report a novel heptamethine cyanine dye-based nanoscale coordination polymer (NCP), Hf-HI-4COOH, as an exceptionally effective photosensitizer for nucleus-targeting low temperature PTT. Hf-HI-4COOH shows strong near-infrared absorption and high photothermal conversion efficiency (39.51 %). Further, it exhibits intrinsic nucleus-targeting property and cell inhibition under low power density in vitro. Moreover, the long blood circulation, high tumor accumulation, and nucleus-targeting contribute to significant inhibition of breast tumors in tumor-bearing mice under low temperature (48 degrees C) and power density (0.3 W/cm(2)) without obvious toxicity. In general, we establish a nucleus-targeting Hf-HI-4COOH for enhanced PTT with low temperature and power density. (C) 2020 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20442]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Li, J 2.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, CAS Key Lab Magnet Mat & Devices, Zhejiang Engn Res Ctr Biomed Mat,Ningbo Inst Mat, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Jiang, Zhenqi,Yuan, Bo,Wang, Yinjie,et al. Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy[J]. NANO TODAY,2020,34. |
| APA | Jiang, Zhenqi.,Yuan, Bo.,Wang, Yinjie.,Wei, Zhenni.,Sun, Shan.,...&Wu, Aiguo.(2020).Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy.NANO TODAY,34. |
| MLA | Jiang, Zhenqi,et al."Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy".NANO TODAY 34(2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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