Facile synthesis of Au@Mn(3)O(4)magneto-plasmonic nanoflowers forT(1)-weighted magnetic resonance imaging and photothermal therapy of cancer
文献类型：期刊论文
| 作者 | Dar, Gohar Ijaz; Iqbal, M. Zubair; Akakuru, Ozioma Udochukwu; Yao, Chenyang; Awiaz, Gul; Wu, Aiguo |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2020 |
| 卷号 | 8期号:36页码:8356-8367 |
| 关键词 | SELECTIVE DUAL FUNCTIONALIZATION MRI CONTRAST AGENTS OXIDE NANOPARTICLES GOLD NANOPARTICLES NANOSTRUCTURES |
| DOI | 10.1039/d0tb01526a |
| 英文摘要 | The integration of advanced diagnostic contrast agents with versatile therapeutic drugs is an effective method for cancer treatment. However, combining various biocompatible theranostic modalities into a single platform at the nanoscale is a challenging assignment. In this work, we report a simple chemical synthetic route for producing a homogeneous hybrid nanoflower shaped morphology based on Au@Mn(3)O(4)magneto-plasmonic nanomaterials. The synthetic mechanism of the nanoflowers is well-matched with the heteroepitaxial growth phenomena by which the nano-petals of Mn(3)O(4)generated on the surface of the Au core. The food and drug administration (FDA) in the USA approved the use of triblock polymer Pluronic F-127 to enhance the biocompatibility of Au@Mn(3)O(4)hybrid nanoflowers. The prepared hybrid nanoflowers produce a significant photothermal heating effect with a thermal transduction efficiency of 38%, comparable to the nanorods and nanoparticles of gold (Au). The hybrid junction reveals promising optical and magnetic properties and the prepared Au@Mn(3)O(4)nanoflowers not only exhibit strong near-infrared (NIR) absorption to produce excellent photothermal efficacy under irradiation with an 808 nm NIR laser, but also demonstrate a significantT(1)-weighted magnetic resonance (MR) image enhancementin vitroandin vivo. The histopathology assessments indicate only negligible toxicity of the nanoflowers to major organs. Therefore, the hybrid Au@Mn(3)O(4)nanoflowers exhibit great potential inT(1)-weighted MR-imaging and photothermal therapy, opening up new possibilities for synthesizing novel bio-compatible, homogeneous, and shape controllable nanostructures with multifunctional applications. |
| 学科主题 | Materials Science |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20479]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Peoples R China. 2.Iqbal, MZ 3.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, Ningbo 315201, Peoples R China. 4.Iqbal, MZ (corresponding author), Zhejiang Sci Tech Univ, Sch Mat Sci & Engn, 2 Rd Niasha, Hangzhou 310018, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Dar, Gohar Ijaz,Iqbal, M. Zubair,Akakuru, Ozioma Udochukwu,et al. Facile synthesis of Au@Mn(3)O(4)magneto-plasmonic nanoflowers forT(1)-weighted magnetic resonance imaging and photothermal therapy of cancer[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(36):8356-8367. |
| APA | Dar, Gohar Ijaz,Iqbal, M. Zubair,Akakuru, Ozioma Udochukwu,Yao, Chenyang,Awiaz, Gul,&Wu, Aiguo.(2020).Facile synthesis of Au@Mn(3)O(4)magneto-plasmonic nanoflowers forT(1)-weighted magnetic resonance imaging and photothermal therapy of cancer.JOURNAL OF MATERIALS CHEMISTRY B,8(36),8356-8367. |
| MLA | Dar, Gohar Ijaz,et al."Facile synthesis of Au@Mn(3)O(4)magneto-plasmonic nanoflowers forT(1)-weighted magnetic resonance imaging and photothermal therapy of cancer".JOURNAL OF MATERIALS CHEMISTRY B 8.36(2020):8356-8367. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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