A Hybrid Organo-Nanotheranostic Platform of Superlative Biocompatibility for Near-Infrared-Triggered Fluorescence Imaging and Synergistically Enhanced Ablation of Tumors
文献类型：期刊论文
| 作者 | Akakuru, Ozioma Udochukwu; Liu, Chuang; Iqbal, M. Zubair; Dar, Gohar Ijaz; Yang, Gao; Qian, Kun; Nosike, Elvis Ikechukwu; Xing, Jie; Zhang, Zhoujing; Li, Yanying |
| 刊名 | SMALL
 |
| 出版日期 | 2020 |
| 卷号 | 16期号:41 |
| 关键词 | PHOTOTHERMAL THERAPY INDOCYANINE GREEN CARBON NANOTUBES CHITOSAN NANOPARTICLES NANOCOMPOSITES DOXORUBICIN STABILITY REMOVAL LIGHT |
| DOI | 10.1002/smll.202002445 |
| 英文摘要 | The quest for an all-organic nanosystem with negligible cytotoxicity and remarkable in vivo tumor theranostic capability is inescapably unending. Hitherto, the landscape of available photothermal agents is dominated by metal-based nanoparticles (NPs) with attendant in vivo negatives. Here, an all-organic-composed theranostic nanosystem with outstanding biocompatibility for fluorescence image-guided tumor photothermal therapy, and as a potential alternative to metal-based photothermal agents is developed. This is rationally achieved by compartmentalizing indocyanine green (ICG) in glycol chitosan (GC)-polypyrrole (PP) nanocarrier to form hybrid ICG@GC-PP NPs (approximate to 65 nm). The compartmentalization strategy, alongside the high photothermal conversion ability of PP jointly enhances the low photostability of free ICG. Advantageously, ICG@GC-PP is endowed with an impeccable in vivo performance by the well-known biocompatibility track records of its individual tri organo-components (GC, PP, and ICG). As a proof of concept, ICG@GC-PP NPs enables a sufficiently prolonged tumor diagnosis by fluorescence imaging up to 20 h post-injection. Furthermore, owing to the complementary heating performances of PP and ICG, ICG@GC-PP NPs-treated mice by one-time near-infrared irradiation exhibit total tumor regression within 14 days post-treatment. Therefore, leveraging the underlying benefits of this study will help to guide the development of new all-organic biocompatible systems in synergism, for safer tumor theranostics. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20494]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 2.Iqbal, MZ 3.Li, J 4.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Engn Res Ctr Biomed Mat, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 5.Iqbal, MZ (corresponding author), Zhejiang Sci Tech Univ, Sch Mat Sci & Engn, 2 Rd Xiasha, Hangzhou 310018, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Akakuru, Ozioma Udochukwu,Liu, Chuang,Iqbal, M. Zubair,et al. A Hybrid Organo-Nanotheranostic Platform of Superlative Biocompatibility for Near-Infrared-Triggered Fluorescence Imaging and Synergistically Enhanced Ablation of Tumors[J]. SMALL,2020,16(41). |
| APA | Akakuru, Ozioma Udochukwu.,Liu, Chuang.,Iqbal, M. Zubair.,Dar, Gohar Ijaz.,Yang, Gao.,...&Wu, Aiguo.(2020).A Hybrid Organo-Nanotheranostic Platform of Superlative Biocompatibility for Near-Infrared-Triggered Fluorescence Imaging and Synergistically Enhanced Ablation of Tumors.SMALL,16(41). |
| MLA | Akakuru, Ozioma Udochukwu,et al."A Hybrid Organo-Nanotheranostic Platform of Superlative Biocompatibility for Near-Infrared-Triggered Fluorescence Imaging and Synergistically Enhanced Ablation of Tumors".SMALL 16.41(2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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