Dual-crosslinked hyaluronan hydrogels with rapid gelation and high injectability for stem cell protection
文献类型：期刊论文
| 作者 | Han, Chenggang; Zhang, Hua; Wu, Yidong; He, Xiuchao; Chen, Xianwu |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2020 |
| 卷号 | 10期号:1 |
| 关键词 | LINKING CHITOSAN ALGINATE |
| DOI | 10.1038/s41598-020-71462-4 |
| 英文摘要 | Injectable dynamic hydrogels play a key role in cell transplantation to protect the cells from shear stress during injection. However, it still remains challenging to design dynamic hydrogels with fast gelation and high stability for protecting cells under flow due to the slow formation and exchange of most dynamic bonds. Here, a novel dual-crosslinked hydrogel system with fast dynamic crosslinks is developed by using methacrylate chitosan (CHMA) and aldehyde functionalized hyaluronate (oxidized HA, OHA). Based on the cooperation of electrostatic interaction between cationic amino of chitosan and anionic carboxyl of HA and Schiff-based crosslinking through amino and aldehyde groups, the dynamic CHMA-OHA hydrogel shows rapid gelation and high injectability. Further, the CHMA-OHA hydrogel is photopolymerized for achieving a high modulus and stability. Importantly, such hydrogels loaded with stem cells remains a cell viability (similar to 92%) after extrusion. These results indicate that the CHMA-OHA hydrogel is a promising tissue engineering biomaterial for therapeutic cell delivery and 3D printing of encapsulated cell scaffolds. |
| 学科主题 | Science & Technology - Other Topics |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20503]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Chen, XW (corresponding author), Ningbo Univ, Affiliated Hosp, Med Sch, Ningbo 315020, Peoples R China. 2.Zhang, H (corresponding author), Xian Univ Technol, Sch Mat Sci & Engn, Xian 710048, Peoples R China. 3.Zhang, H (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Han, Chenggang,Zhang, Hua,Wu, Yidong,et al. Dual-crosslinked hyaluronan hydrogels with rapid gelation and high injectability for stem cell protection[J]. SCIENTIFIC REPORTS,2020,10(1). |
| APA | Han, Chenggang,Zhang, Hua,Wu, Yidong,He, Xiuchao,&Chen, Xianwu.(2020).Dual-crosslinked hyaluronan hydrogels with rapid gelation and high injectability for stem cell protection.SCIENTIFIC REPORTS,10(1). |
| MLA | Han, Chenggang,et al."Dual-crosslinked hyaluronan hydrogels with rapid gelation and high injectability for stem cell protection".SCIENTIFIC REPORTS 10.1(2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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