Tumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon-Dot-Cu(2+)Nanoassemblies
文献类型：期刊论文
| 作者 | Sun, Shan; Chen, Qiao; Tang, Zhongdi; Liu, Chuang; Li, Zhongjun; Wu, Aiguo; Lin, Hengwei |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020 |
| 卷号 | 59期号:47页码:21041-21048 |
| 关键词 | CARBON DOTS QUANTUM DOTS OXIDATION EFFICIENT |
| DOI | 10.1002/anie.202007786 |
| 英文摘要 | A method is developed to fabricate tumor microenvironment (TME) stimuli-responsive nanoplatform for fluorescence (FL) imaging and synergistic cancer therapy via assembling photosensitizer (chlorine e6, Ce6) modified carbon dots (CDs-Ce6) and Cu2+. The as-obtained nanoassemblies (named Cu/CC nanoparticles, NPs) exhibit quenched FL and photosensitization due to the aggregation of CDs-Ce6. Their FL imaging and photodynamic therapy (PDT) functions are recovered efficiently once they entering tumor sites by the stimulation of TME. Introducing of Cu(2+)not only provides extra chemodynamic therapy (CDT) function through reaction with hydrogen peroxide (H2O2), but also depletes GSH in tumors by a redox reaction, thus amplifying the intracellular oxidative stress and enhancing the efficacy of reactive oxygen species (ROS) based therapy. Cu/CC NPs can act as a FL imaging guided trimodal synergistic cancer treatment agent by photothermal therapy (PTT), PDT, and thermally amplified CDT. |
| 学科主题 | Chemistry |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20508]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Lin, HW (corresponding author), Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Ningbo Inst Mat Technol & Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 2.Lin, HW (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, Key Lab Magnet Mat & Devices, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Sun, Shan,Chen, Qiao,Tang, Zhongdi,et al. Tumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon-Dot-Cu(2+)Nanoassemblies[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020,59(47):21041-21048. |
| APA | Sun, Shan.,Chen, Qiao.,Tang, Zhongdi.,Liu, Chuang.,Li, Zhongjun.,...&Lin, Hengwei.(2020).Tumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon-Dot-Cu(2+)Nanoassemblies.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,59(47),21041-21048. |
| MLA | Sun, Shan,et al."Tumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon-Dot-Cu(2+)Nanoassemblies".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59.47(2020):21041-21048. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。