Recent progress in the detection and treatment of atherosclerosis by nanoparticles
文献类型：期刊论文
| 作者 | Chen, L.; Jiang, Z.; Akakuru, O. U.; Yang, L.; Li, J.; Ma, S.; Wu, A. |
| 刊名 | MATERIALS TODAY CHEMISTRY
 |
| 出版日期 | 2020 |
| 卷号 | 17 |
| 关键词 | MAGNETIC-RESONANCE MRI DETECTION MACROPHAGES INFLAMMATION PLAQUE RECEPTOR DELIVERY LESIONS REDUCTION TISSUE |
| DOI | 10.1016/j.mtchem.2020.100280 |
| 英文摘要 | Cardiovascular diseases (CVDs) have high mortality and morbidity in the US and presently rank as one of the leading causes of death. Atherosclerosis (AS) acts as one of the CVDs, playing an important role in mortality because of many lethal complications. The common cause of AS is that low-density lipoprotein (LDL) in the blood circulation enters the intima through endothelial cells that have been broken for various reasons. Under the action of inflammatory factors secreted by damaged endothelial cells, monocytes also enter the inner membrane and differentiate into macrophages. Macrophages engulf the oxidized LDL and become foam cells which eventually become apoptotic. However, recent studies have shown that LDL entry into the intima, an important step in AS, may be associated with endothelial cells actively inhaling LDL through the receptor. Nanotechnology is a promising technology that can be applied in the noninvasive imaging and therapy of AS. Nanoparticles (NPs) have the ability to passively target AS because of their inherent small diameter. They can also be loaded with chemicals for targeting lesions, contrast agents for imaging, and drugs for treatment to achieve accurate diagnosis and treatment of AS. This review consequently highlights the recent progress in the detection and treatment of AS by NPs. (C) 2020 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry ; Materials Science |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20527]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Ma, S (corresponding author), Ningbo Yinzhou 2 Hosp, Ningbo 315192, Peoples R China. 2.Li, J 3.Wu, A (corresponding author), Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn,CAS Key Lab Magnet Mat & De, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Chen, L.,Jiang, Z.,Akakuru, O. U.,et al. Recent progress in the detection and treatment of atherosclerosis by nanoparticles[J]. MATERIALS TODAY CHEMISTRY,2020,17. |
| APA | Chen, L..,Jiang, Z..,Akakuru, O. U..,Yang, L..,Li, J..,...&Wu, A..(2020).Recent progress in the detection and treatment of atherosclerosis by nanoparticles.MATERIALS TODAY CHEMISTRY,17. |
| MLA | Chen, L.,et al."Recent progress in the detection and treatment of atherosclerosis by nanoparticles".MATERIALS TODAY CHEMISTRY 17(2020). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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