Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y-1 receptor-overexpressed breast cancer
文献类型：期刊论文
| 作者 | Qian, Xuechen; Wang, Yinjie; Xu, Youfeng; Ma, Ling; Xue, Nianyu; Jiang, Zhenqi; Cao, Yi; Akakuru, Ozioma Udochukwu; Li, Juan; Zhang, Shengmin |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2020 |
| 卷号 | 8期号:31页码:6837-6844 |
| 关键词 | NEUROPEPTIDE-Y MICROBUBBLE DELIVERY DRUG COMPLEX |
| DOI | 10.1039/d0tb00556h |
| 英文摘要 | Ultrasound cavitation therapy has attracted much attention in recent years because the cavitation of microbubbles can be leveraged to boost the infiltration of chemotherapeutic drugs into cancer tissues. For breast cancer therapy, most of the previously reported microbubbles lack specific targeting capacity and permeability. In this study, we have successfully fabricated Y-1 receptor ligand (NPY)-modified bubbles, and examined their therapeutic efficacies as size-dependent functions with or without NPY targeting. To achieve this, four types of micro-scale bubbles (MBs or MBs-NPY) and nano-scale bubbles (NBs or NBs-NPY) were comprehensively evaluated. In vivo results indicated that the NBs-NPY group with doxorubicin (DOX) under ultrasound irradiation showed a high tumor suppression effect and a prolonged survival time. Furthermore, the NBs-NPY with DOX group exhibited minimal damage to mouse vital organs, which points to the considerable tolerance of the proposed nanosystem for efficacious breast cancer therapy. In summary, these findings suggest that the developed NPY-targeted NBs could have a broad application prospect in ultrasound cavitation chemotherapy of Y-1 receptor-overexpressed breast cancer. |
| 学科主题 | Materials Science |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20568]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Zhang, SM (corresponding author), Ningbo First Hosp, Dept Ultrasound, Ningbo 315010, Peoples R China. 2.Li, J 3.Wu, AG (corresponding author), Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn,CAS Key Lab Magnet Mat & De, Ningbo 315201, Peoples R China. 4.Zhang, SM (corresponding author), Ningbo Univ, Med Sch, Ningbo 315211, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Qian, Xuechen,Wang, Yinjie,Xu, Youfeng,et al. Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y-1 receptor-overexpressed breast cancer[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(31):6837-6844. |
| APA | Qian, Xuechen.,Wang, Yinjie.,Xu, Youfeng.,Ma, Ling.,Xue, Nianyu.,...&Wu, Aiguo.(2020).Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y-1 receptor-overexpressed breast cancer.JOURNAL OF MATERIALS CHEMISTRY B,8(31),6837-6844. |
| MLA | Qian, Xuechen,et al."Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y-1 receptor-overexpressed breast cancer".JOURNAL OF MATERIALS CHEMISTRY B 8.31(2020):6837-6844. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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